Cargando…

Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases

OBJECTIVES: We assessed the current genetic evidence for the involvement of various cell types and tissue types in the etiology of neurodegenerative diseases, especially in relation to the neuroinflammatory hypothesis of neurodegenerative diseases. METHODS: We obtained large‐scale genome‐wide associ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gagliano, Sarah A., Pouget, Jennie G., Hardy, John, Knight, Jo, Barnes, Michael R., Ryten, Mina, Weale, Michael E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224821/ https://www.ncbi.nlm.nih.gov/pubmed/28097204 http://dx.doi.org/10.1002/acn3.369

Ejemplares similares

A Bayesian Method to Incorporate Hundreds of Functional Characteristics with Association Evidence to Improve Variant Prioritization
por: Gagliano, Sarah A., et al.
Publicado: (2014)

The Innate and Adaptive Immune Cells in Alzheimer's and Parkinson's Diseases
por: Huang, Boyuan, et al.
Publicado: (2022)

Smoking Gun or Circumstantial Evidence? Comparison of Statistical Learning Methods using Functional Annotations for Prioritizing Risk Variants
por: Gagliano, Sarah A., et al.
Publicado: (2015)

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability
por: Reynolds, Regina H., et al.
Publicado: (2019)

Informing disease modelling with brain-relevant functional genomic annotations
por: Reynolds, Regina H, et al.
Publicado: (2019)

Assessing models for genetic prediction of complex traits: a comparison of visualization and quantitative methods
por: Gagliano, Sarah A., et al.
Publicado: (2015)

Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies
por: Trabzuni, Daniah, et al.
Publicado: (2011)

Analysis of subcellular RNA fractions demonstrates significant genetic regulation of gene expression in human brain post-transcriptionally
por: D’Sa, Karishma, et al.
Publicado: (2023)

Heritability Enrichment Implicates Microglia in Parkinson’s Disease Pathogenesis
por: Andersen, Maren Stolp, et al.
Publicado: (2021)

Periphery and brain, innate and adaptive immunity in Parkinson’s disease
por: Harms, Ashley S., et al.
Publicado: (2021)

Widespread sex differences in gene expression and splicing in the adult human brain
por: Trabzuni, Daniah, et al.
Publicado: (2013)

Using Functional Annotation for the Empirical Determination of Bayes Factors for Genome-Wide Association Study Analysis
por: Knight, Jo, et al.
Publicado: (2011)

Regional genetic correlations highlight relationships between neurodegenerative disease loci and the immune system
por: Lona-Durazo, Frida, et al.
Publicado: (2023)

Genome-Wide Association Studies Suggest Limited Immune Gene Enrichment in Schizophrenia Compared to 5 Autoimmune Diseases
por: Pouget, Jennie G., et al.
Publicado: (2016)

Genetic evidence for a pathogenic role for the vitamin D3 metabolizing enzyme CYP24A1 in multiple sclerosis()
por: Ramasamy, Adaikalavan, et al.
Publicado: (2014)

The Complexity of Microglial Interactions With Innate and Adaptive Immune Cells in Alzheimer’s Disease
por: Wyatt-Johnson, Season K., et al.
Publicado: (2020)

An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks
por: Botía, Juan A., et al.
Publicado: (2017)

Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis
por: Ferrari, Raffaele, et al.
Publicado: (2016)

Zinc in innate and adaptive tumor immunity
por: John, Erica, et al.
Publicado: (2010)

Aspects of Innate Immunity and Parkinson’s Disease
por: Huang, Yue, et al.
Publicado: (2012)

Neutrophils: Their Role in Innate and Adaptive Immunity 2017
por: Rosales, Carlos, et al.
Publicado: (2017)

Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases
por: Reynolds, Regina H., et al.
Publicado: (2023)

Author Correction: Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases
por: Reynolds, Regina H., et al.
Publicado: (2023)

The Role of Bacteria–Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson’s Disease
por: Magalhães, João D., et al.
Publicado: (2023)

Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy
por: Ferrari, Raffaele, et al.
Publicado: (2014)

Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease
por: Sfera, Adonis, et al.
Publicado: (2018)

Innate-Adaptive Immune Crosstalk
por: Shanker, Anil, et al.
Publicado: (2015)

Innate and Adaptive Immunity to Mucorales
por: Ghuman, Harlene, et al.
Publicado: (2017)

Adaptive and Innate Immunity in Psoriasis and Other Inflammatory Disorders
por: Schön, Michael P.
Publicado: (2019)

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
por: Hughes, Craig D., et al.
Publicado: (2018)

The Innate Immune System in Alzheimer's Disease
por: Boutajangout, Allal, et al.
Publicado: (2013)

Editorial: Crosstalk between innate and adaptive immunity in colorectal cancer: Implications for immunotherapy
por: Jarry, Anne, et al.
Publicado: (2023)

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis
por: Patani, Rickie, et al.
Publicado: (2012)

Annexin A1 and the regulation of innate and adaptive immunity
por: Gavins, Felicity N. E., et al.
Publicado: (2012)

Corrigendum to “Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy.” [Neurobiol. Aging 35 (2014) 1514.e1–1514.e12]
por: Ferrari, Raffaele, et al.
Publicado: (2015)

Genome-wide Analysis of Motor Progression in Parkinson Disease
por: Martínez Carrasco, Alejandro, et al.
Publicado: (2023)

A central role for mitochondrial-derived vesicles in the innate immune response: implications for Parkinson’s disease
por: Ryan, Thomas A., et al.
Publicado: (2021)

To TRIM the Immunity: From Innate to Adaptive Immunity
por: Yang, Wenyong, et al.
Publicado: (2020)

Trained Immunity as an Adaptive Branch of Innate Immunity
por: Vetvicka, Vaclav, et al.
Publicado: (2021)

Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information
por: Guelfi, Sebastian, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jl2v1ddcnfj7cv34apip0vrbjf