Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease

In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [(18)F]AV‐1451) and beta‐amyloid burden (measured with [(11)C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [(18)F]FDG‐PET) in patients with Alzhe...

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Autores principales: Bischof, Gérard N., Jessen, Frank, Fliessbach, Klaus, Dronse, Julian, Hammes, Jochen, Neumaier, Bernd, Onur, Oezguer, Fink, Gereon R., Kukolja, Juraj, Drzezga, Alexander, van Eimeren, Thilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224823/
https://www.ncbi.nlm.nih.gov/pubmed/28097205
http://dx.doi.org/10.1002/acn3.339
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author Bischof, Gérard N.
Jessen, Frank
Fliessbach, Klaus
Dronse, Julian
Hammes, Jochen
Neumaier, Bernd
Onur, Oezguer
Fink, Gereon R.
Kukolja, Juraj
Drzezga, Alexander
van Eimeren, Thilo
author_facet Bischof, Gérard N.
Jessen, Frank
Fliessbach, Klaus
Dronse, Julian
Hammes, Jochen
Neumaier, Bernd
Onur, Oezguer
Fink, Gereon R.
Kukolja, Juraj
Drzezga, Alexander
van Eimeren, Thilo
author_sort Bischof, Gérard N.
collection PubMed
description In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [(18)F]AV‐1451) and beta‐amyloid burden (measured with [(11)C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [(18)F]FDG‐PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta‐amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta‐amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβ and tau to neurodegeneration in Alzheimer's disease.
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spelling pubmed-52248232017-01-17 Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease Bischof, Gérard N. Jessen, Frank Fliessbach, Klaus Dronse, Julian Hammes, Jochen Neumaier, Bernd Onur, Oezguer Fink, Gereon R. Kukolja, Juraj Drzezga, Alexander van Eimeren, Thilo Ann Clin Transl Neurol Brief Communications In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [(18)F]AV‐1451) and beta‐amyloid burden (measured with [(11)C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [(18)F]FDG‐PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta‐amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta‐amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβ and tau to neurodegeneration in Alzheimer's disease. John Wiley and Sons Inc. 2016-10-20 /pmc/articles/PMC5224823/ /pubmed/28097205 http://dx.doi.org/10.1002/acn3.339 Text en © 2016 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Bischof, Gérard N.
Jessen, Frank
Fliessbach, Klaus
Dronse, Julian
Hammes, Jochen
Neumaier, Bernd
Onur, Oezguer
Fink, Gereon R.
Kukolja, Juraj
Drzezga, Alexander
van Eimeren, Thilo
Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease
title Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease
title_full Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease
title_fullStr Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease
title_full_unstemmed Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease
title_short Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease
title_sort impact of tau and amyloid burden on glucose metabolism in alzheimer's disease
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224823/
https://www.ncbi.nlm.nih.gov/pubmed/28097205
http://dx.doi.org/10.1002/acn3.339
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