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Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers

Early‐onset gastric cancer (EOGC) is predominant in females, diffuse histology, and hereditary pattern. Germline mutation of CDH1 and p53 has been reported previously and female dominance was speculated to be associated with estrogen and its receptors. Expression of E‐cadherin, estrogen receptor α (...

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Autores principales: Zhou, Fan, Xu, Yuanyuan, Shi, Jiong, Lan, Xing, Zou, Xiaoping, Wang, Lei, Huang, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224840/
https://www.ncbi.nlm.nih.gov/pubmed/27781410
http://dx.doi.org/10.1002/cam4.931
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author Zhou, Fan
Xu, Yuanyuan
Shi, Jiong
Lan, Xing
Zou, Xiaoping
Wang, Lei
Huang, Qin
author_facet Zhou, Fan
Xu, Yuanyuan
Shi, Jiong
Lan, Xing
Zou, Xiaoping
Wang, Lei
Huang, Qin
author_sort Zhou, Fan
collection PubMed
description Early‐onset gastric cancer (EOGC) is predominant in females, diffuse histology, and hereditary pattern. Germline mutation of CDH1 and p53 has been reported previously and female dominance was speculated to be associated with estrogen and its receptors. Expression of E‐cadherin, estrogen receptor α (ER α), estrogen receptor β (ER β), and p53 in EOGC remains unclear, which was the focus of this study, to assess clinical significance of their expression in EOGC. The expression of E‐cadherin, ER α, ER β, and p53 in tumors and normal tissues from surgically resected EOGCs was assessed by immunohistochemistry (n = 139) and Western blot (n = 7) methods, respectively. The expression in tumor tissues was significantly higher for ER α, ER β, and p53, but lower for E‐cadherin, compared to uninvolved mucosa. Positive staining of ER β and p53 was more frequently observed in younger patients with advanced TNM stages. For E‐cadherin, significant correlation was observed between the immunopositivity and TNM stages IA+IB. P53‐negative patients had significantly better outcomes than p53‐positive patients. Significant association between expression of E‐cadherin and histologic types was found in familial, but not in sporadic, EOGC. In conclusion, our results demonstrated E‐cadherin may have a role in initiation of EOGC and positive ER β and p53 expression may partially explained early‐onset and tumor progression of EOGC.
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spelling pubmed-52248402017-01-17 Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers Zhou, Fan Xu, Yuanyuan Shi, Jiong Lan, Xing Zou, Xiaoping Wang, Lei Huang, Qin Cancer Med Clinical Cancer Research Early‐onset gastric cancer (EOGC) is predominant in females, diffuse histology, and hereditary pattern. Germline mutation of CDH1 and p53 has been reported previously and female dominance was speculated to be associated with estrogen and its receptors. Expression of E‐cadherin, estrogen receptor α (ER α), estrogen receptor β (ER β), and p53 in EOGC remains unclear, which was the focus of this study, to assess clinical significance of their expression in EOGC. The expression of E‐cadherin, ER α, ER β, and p53 in tumors and normal tissues from surgically resected EOGCs was assessed by immunohistochemistry (n = 139) and Western blot (n = 7) methods, respectively. The expression in tumor tissues was significantly higher for ER α, ER β, and p53, but lower for E‐cadherin, compared to uninvolved mucosa. Positive staining of ER β and p53 was more frequently observed in younger patients with advanced TNM stages. For E‐cadherin, significant correlation was observed between the immunopositivity and TNM stages IA+IB. P53‐negative patients had significantly better outcomes than p53‐positive patients. Significant association between expression of E‐cadherin and histologic types was found in familial, but not in sporadic, EOGC. In conclusion, our results demonstrated E‐cadherin may have a role in initiation of EOGC and positive ER β and p53 expression may partially explained early‐onset and tumor progression of EOGC. John Wiley and Sons Inc. 2016-10-25 /pmc/articles/PMC5224840/ /pubmed/27781410 http://dx.doi.org/10.1002/cam4.931 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Zhou, Fan
Xu, Yuanyuan
Shi, Jiong
Lan, Xing
Zou, Xiaoping
Wang, Lei
Huang, Qin
Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers
title Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers
title_full Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers
title_fullStr Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers
title_full_unstemmed Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers
title_short Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers
title_sort expression profile of e‐cadherin, estrogen receptors, and p53 in early‐onset gastric cancers
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224840/
https://www.ncbi.nlm.nih.gov/pubmed/27781410
http://dx.doi.org/10.1002/cam4.931
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