Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED

Polycomb repressive complex 2 (PRC2), a histone H3 lysine 27 methyltransferase, plays a key role in gene regulation and is a known epigenetics drug target for cancer therapy. The WD40 domain-containing protein EED is the regulatory subunit of PRC2. It binds to the tri-methylated lysine 27 of the his...

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Detalles Bibliográficos
Autores principales: Li, Ling, Zhang, Hailong, Zhang, Man, Zhao, Mengxi, Feng, Lijian, Luo, Xiao, Gao, Zhenting, Huang, Ying, Ardayfio, Ophelia, Zhang, Ji-Hu, Lin, Ying, Fan, Hong, Mi, Yuan, Li, Guobin, Liu, Lei, Feng, Leying, Luo, Fangjun, Teng, Lin, Qi, Wei, Ottl, Johannes, Lingel, Andreas, Bussiere, Dirksen E., Yu, Zhengtian, Atadja, Peter, Lu, Chris, Li, En, Gu, Justin, Zhao, Kehao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224880/
https://www.ncbi.nlm.nih.gov/pubmed/28072869
http://dx.doi.org/10.1371/journal.pone.0169855

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