A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes

[Image: see text] Escherichia coli class Ia ribonucleotide reductase (RNR) converts ribonucleotides to deoxynucleotides. A diferric-tyrosyl radical (Y(122)•) in one subunit (β2) generates a transient thiyl radical in another subunit (α2) via long-range radical transport (RT) through aromatic amino a...

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Detalles Bibliográficos
Autores principales: Ravichandran, Kanchana R., Taguchi, Alexander T., Wei, Yifeng, Tommos, Cecilia, Nocera, Daniel G., Stubbe, JoAnne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224885/
https://www.ncbi.nlm.nih.gov/pubmed/28068088
http://dx.doi.org/10.1021/jacs.6b08200

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