APP modulates KCC2 expression and function in hippocampal GABAergic inhibition

Amyloid precursor protein (APP) is enriched at the synapse, but its synaptic function is still poorly understood. We previously showed that GABAergic short-term plasticity is impaired in App knock-out (App(-/-)) animals, but the precise mechanism by which APP regulates GABAergic synaptic transmissio...

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Detalles Bibliográficos
Autores principales: Chen, Ming, Wang, Jinzhao, Jiang, Jinxiang, Zheng, Xingzhi, Justice, Nicholas J, Wang, Kun, Ran, Xiangqian, Li, Yi, Huo, Qingwei, Zhang, Jiajia, Li, Hongmei, Lu, Nannan, Wang, Ying, Zheng, Hui, Long, Cheng, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224924/
https://www.ncbi.nlm.nih.gov/pubmed/28054918
http://dx.doi.org/10.7554/eLife.20142

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