Cargando…

Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis

ABSTRACT: We have demonstrated that the signal transducer and activator of transcription 3 (STAT3) protects from cholestatic liver injury. Specific ablation of STAT3 in hepatocytes and cholangiocytes (STAT3(∆hc)) aggravated liver damage and fibrosis in the Mdr2(−/−) (multidrug resistance 2) mouse mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Svinka, Jasmin, Pflügler, Sandra, Mair, Markus, Marschall, Hanns-Ulrich, Hengstler, Jan G., Stiedl, Patricia, Poli, Valeria, Casanova, Emilio, Timelthaler, Gerald, Sibilia, Maria, Eferl, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225179/ https://www.ncbi.nlm.nih.gov/pubmed/27568040 http://dx.doi.org/10.1007/s00109-016-1462-8

Ejemplares similares

IDO1(+) Paneth cells promote immune escape of colorectal cancer
por: Pflügler, Sandra, et al.
Publicado: (2020)

Defects in microvillus crosslinking sensitize to colitis and inflammatory bowel disease
por: Mödl, Bernadette, et al.
Publicado: (2023)

Ileal Bile Acid Transporter Inhibition for the Treatment of Chronic Constipation, Cholestatic Pruritus, and NASH
por: Al-Dury, Samer, et al.
Publicado: (2018)

STAT1 is a sex‐specific tumor suppressor in colitis‐associated colorectal cancer
por: Crnčec, Ilija, et al.
Publicado: (2018)

Variant adiponutrin confers genetic protection against cholestatic itch
por: Krawczyk, Marcin, et al.
Publicado: (2014)

Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis
por: Gui, Wenfang, et al.
Publicado: (2023)

Pilot study with IBAT inhibitor A4250 for the treatment of cholestatic pruritus in primary biliary cholangitis
por: Al-Dury, Samer, et al.
Publicado: (2018)

Tyk2 is a tumor suppressor in colorectal cancer
por: Moritsch, Stefan, et al.
Publicado: (2022)

Fibrosis in Autoimmune and Cholestatic Liver Disease
por: Penz-Österreicher, Melitta, et al.
Publicado: (2011)

Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease
por: Lemberger, Ursula J., et al.
Publicado: (2016)

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis
por: Grabner, Beatrice, et al.
Publicado: (2015)

Upregulation of cadherin‐11 contributes to cholestatic liver fibrosis
por: Wu, Bo, et al.
Publicado: (2022)

Tetrahydroxylated bile acids improve cholestatic liver and bile duct injury in the Mdr2(−/−) mouse model of sclerosing cholangitis via immunomodulatory effects
por: Fuchs, Claudia D., et al.
Publicado: (2022)

Colesevelam attenuates cholestatic liver and bile duct injury in Mdr2(−/−) mice by modulating composition, signalling and excretion of faecal bile acids
por: Fuchs, Claudia Daniela, et al.
Publicado: (2018)

Genetically modified mouse models of cancer invasion and metastasis
por: Rampetsreiter, Paulina, et al.
Publicado: (2011)

Intrahepatic Cholestasis of Pregnancy Levels of Sulfated Progesterone Metabolites Inhibit Farnesoid X Receptor Resulting in a Cholestatic Phenotype
por: Abu-Hayyeh, Shadi, et al.
Publicado: (2013)

Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice
por: Pathria, Paulina, et al.
Publicado: (2015)

Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy
por: Ovadia, Caroline, et al.
Publicado: (2020)

Generation of metastatic melanoma specific antibodies by affinity purification
por: Schütz, Birgit, et al.
Publicado: (2016)

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions
por: Moll, Herwig P., et al.
Publicado: (2019)

The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis
por: Fuji, Hiroaki, et al.
Publicado: (2021)

Giant Cell Arteritis Presenting as Cholestatic Hepatitis
por: Riordan, Gerald, et al.
Publicado: (2021)

AKT3 drives adenoid cystic carcinoma development in salivary glands
por: Zboray, Katalin, et al.
Publicado: (2017)

Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis
por: Gong, Zizhen, et al.
Publicado: (2016)

ERRγ suppression by Sirt6 alleviates cholestatic liver injury and fibrosis
por: Hao, Lihua, et al.
Publicado: (2020)

Inhibition of CBP/β‐catenin signaling ameliorated fibrosis in cholestatic liver disease
por: Kimura, Masamichi, et al.
Publicado: (2022)

Combi-Elasto Evaluation of the Degree of Liver Fibrosis in Children with Cholestatic Liver Disease
por: Li, Rina, et al.
Publicado: (2023)

Evaluation and Management of Chronic Cholestatic Liver Diseases
por: Rini, Sandra Surya, et al.
Publicado: (2023)

Bacterial artificial chromosomes improve recombinant protein production in mammalian cells
por: Blaas, Leander, et al.
Publicado: (2009)

Hepatobiliary Thyroid Hormone Deficiency Impacts Bile Acid Hydrophilicity and Aquaporins in Cholestatic C57BL/6J Mice
por: Kube, Irina, et al.
Publicado: (2022)

Why Doesn’t Primary Biliary Cholangitis Respond to Immunosuppressive Medications?
por: Molinaro, Antonio, et al.
Publicado: (2017)

Cholestatic Hepatitis as a Possible Paraneoplastic Syndrome of Endometrial Carcinoma
por: Wade, Francis Gerald, et al.
Publicado: (2020)

Cholestatic hepatitis with intravenous ceftriaxone
por: Kaur, Inderpal, et al.
Publicado: (2011)

Azathioprine induced cholestatic hepatitis
por: Moses, Viju, et al.
Publicado: (2011)

Trifluoperazine-Induced Cholestatic Jaundice
por: Sharifi, Vandad, et al.
Publicado: (2010)

Cephalexin Induced Cholestatic Jaundice
por: Agrawal, Abhinav, et al.
Publicado: (2014)

Azithromycin-induced cholestatic hepatitis
por: Koffas, Apostolos, et al.
Publicado: (2017)

Current Therapies for Cholestatic Diseases
por: Méndez-Sánchez, Nahum, et al.
Publicado: (2023)

Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis
por: Li, Sha, et al.
Publicado: (2021)

The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness
por: Schmidt, Ulrike, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dstppqvt0mmfs4kf5p6voardc8