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Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system
The microbiome located within a given host and its organs forms a holobiont, an intimate functional entity with evolutionarily designed interactions to support nutritional intake and reproduction. Thus, all organs in a holobiont respond to changes within the microbiome. The development and function...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225196/ https://www.ncbi.nlm.nih.gov/pubmed/27858116 http://dx.doi.org/10.1007/s00109-016-1486-0 |
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author | Lee, Hae Ung McPherson, Zachary E Tan, Bryan Korecka, Agata Pettersson, Sven |
author_facet | Lee, Hae Ung McPherson, Zachary E Tan, Bryan Korecka, Agata Pettersson, Sven |
author_sort | Lee, Hae Ung |
collection | PubMed |
description | The microbiome located within a given host and its organs forms a holobiont, an intimate functional entity with evolutionarily designed interactions to support nutritional intake and reproduction. Thus, all organs in a holobiont respond to changes within the microbiome. The development and function of the central nervous system and its homeostatic mechanisms are no exception and are also subject to regulation by the gut microbiome. In order for the holobiont to function effectively, the microbiome and host must communicate. The aryl hydrocarbon receptor is an evolutionarily conserved receptor recognizing environmental compounds, including a number of ligands produced directly and indirectly by the microbiome. This review focuses on the microbiome-gut-brain axis in regard to the aryl hydrocarbon receptor signaling pathway and its impact on underlying mechanisms in neurodegeneration. |
format | Online Article Text |
id | pubmed-5225196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-52251962017-01-24 Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system Lee, Hae Ung McPherson, Zachary E Tan, Bryan Korecka, Agata Pettersson, Sven J Mol Med (Berl) Review The microbiome located within a given host and its organs forms a holobiont, an intimate functional entity with evolutionarily designed interactions to support nutritional intake and reproduction. Thus, all organs in a holobiont respond to changes within the microbiome. The development and function of the central nervous system and its homeostatic mechanisms are no exception and are also subject to regulation by the gut microbiome. In order for the holobiont to function effectively, the microbiome and host must communicate. The aryl hydrocarbon receptor is an evolutionarily conserved receptor recognizing environmental compounds, including a number of ligands produced directly and indirectly by the microbiome. This review focuses on the microbiome-gut-brain axis in regard to the aryl hydrocarbon receptor signaling pathway and its impact on underlying mechanisms in neurodegeneration. Springer Berlin Heidelberg 2016-11-17 2017 /pmc/articles/PMC5225196/ /pubmed/27858116 http://dx.doi.org/10.1007/s00109-016-1486-0 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Lee, Hae Ung McPherson, Zachary E Tan, Bryan Korecka, Agata Pettersson, Sven Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system |
title | Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system |
title_full | Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system |
title_fullStr | Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system |
title_full_unstemmed | Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system |
title_short | Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system |
title_sort | host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225196/ https://www.ncbi.nlm.nih.gov/pubmed/27858116 http://dx.doi.org/10.1007/s00109-016-1486-0 |
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