LJM716 in Japanese patients with head and neck squamous cell carcinoma or HER2-overexpressing breast or gastric cancer

PURPOSE: Human epidermal growth factor receptor 3 (HER3) has been identified as an important component of many receptor tyrosine kinase-driven cancers. LJM716 is a human IgG monoclonal antibody that binds HER3, trapping it in an inactive conformation. In this study, a phase I dose escalation was per...

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Detalles Bibliográficos
Autores principales: Takahashi, Shunji, Kobayashi, Takayuki, Tomomatsu, Junichi, Ito, Yoshinori, Oda, Hisanobu, Kajitani, Tatsuhiro, Kakizume, Tomoyuki, Tajima, Takeshi, Takeuchi, Hiromi, Maacke, Heiko, Esaki, Taito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225197/
https://www.ncbi.nlm.nih.gov/pubmed/27942917
http://dx.doi.org/10.1007/s00280-016-3214-4

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