A simplified and scalable synthesis of artesunate

ABSTRACT: An efficient and economically viable approach for the large-scale conversion of artemisinin into the antimalarial frontline drug artesunate was developed. This advanced synthesis includes an NaBH(4)-induced reduction, followed by an esterification with succinic anhydride under basic condit...

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Detalles Bibliográficos
Autores principales: Presser, Armin, Feichtinger, Andrea, Buzzi, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225229/
https://www.ncbi.nlm.nih.gov/pubmed/28127092
http://dx.doi.org/10.1007/s00706-016-1865-9
Descripción
Sumario:ABSTRACT: An efficient and economically viable approach for the large-scale conversion of artemisinin into the antimalarial frontline drug artesunate was developed. This advanced synthesis includes an NaBH(4)-induced reduction, followed by an esterification with succinic anhydride under basic conditions. The entire conversion follows the principles of green chemistry, i.e., application of reusable solvents. GRAPHICAL ABSTRACT: [Image: see text]

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