A simplified and scalable synthesis of artesunate

ABSTRACT: An efficient and economically viable approach for the large-scale conversion of artemisinin into the antimalarial frontline drug artesunate was developed. This advanced synthesis includes an NaBH(4)-induced reduction, followed by an esterification with succinic anhydride under basic condit...

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Detalles Bibliográficos
Autores principales: Presser, Armin, Feichtinger, Andrea, Buzzi, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225229/
https://www.ncbi.nlm.nih.gov/pubmed/28127092
http://dx.doi.org/10.1007/s00706-016-1865-9
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author Presser, Armin
Feichtinger, Andrea
Buzzi, Silke
author_facet Presser, Armin
Feichtinger, Andrea
Buzzi, Silke
author_sort Presser, Armin
collection PubMed
description ABSTRACT: An efficient and economically viable approach for the large-scale conversion of artemisinin into the antimalarial frontline drug artesunate was developed. This advanced synthesis includes an NaBH(4)-induced reduction, followed by an esterification with succinic anhydride under basic conditions. The entire conversion follows the principles of green chemistry, i.e., application of reusable solvents. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-52252292017-01-24 A simplified and scalable synthesis of artesunate Presser, Armin Feichtinger, Andrea Buzzi, Silke Monatsh Chem Original Paper ABSTRACT: An efficient and economically viable approach for the large-scale conversion of artemisinin into the antimalarial frontline drug artesunate was developed. This advanced synthesis includes an NaBH(4)-induced reduction, followed by an esterification with succinic anhydride under basic conditions. The entire conversion follows the principles of green chemistry, i.e., application of reusable solvents. GRAPHICAL ABSTRACT: [Image: see text] Springer Vienna 2016-12-02 2017 /pmc/articles/PMC5225229/ /pubmed/28127092 http://dx.doi.org/10.1007/s00706-016-1865-9 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Presser, Armin
Feichtinger, Andrea
Buzzi, Silke
A simplified and scalable synthesis of artesunate
title A simplified and scalable synthesis of artesunate
title_full A simplified and scalable synthesis of artesunate
title_fullStr A simplified and scalable synthesis of artesunate
title_full_unstemmed A simplified and scalable synthesis of artesunate
title_short A simplified and scalable synthesis of artesunate
title_sort simplified and scalable synthesis of artesunate
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225229/
https://www.ncbi.nlm.nih.gov/pubmed/28127092
http://dx.doi.org/10.1007/s00706-016-1865-9
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