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A simplified and scalable synthesis of artesunate
ABSTRACT: An efficient and economically viable approach for the large-scale conversion of artemisinin into the antimalarial frontline drug artesunate was developed. This advanced synthesis includes an NaBH(4)-induced reduction, followed by an esterification with succinic anhydride under basic condit...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Vienna
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225229/ https://www.ncbi.nlm.nih.gov/pubmed/28127092 http://dx.doi.org/10.1007/s00706-016-1865-9 |