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Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review

Background. As part of regional elimination efforts, rubella-containing vaccines (RCV) have recently been introduced in the Philippines, yet the true burden of rubella and congenital rubella syndrome (CRS) in the country is largely unknown. Objective. To provide baseline information on rubella and C...

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Autores principales: Lopez, Anna Lena, Raguindin, Peter Francis N., Silvestre, Maria Asuncion, Fabay, Xenia Cathrine J., Vinarao, Ariel B., Manalastas, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225339/
https://www.ncbi.nlm.nih.gov/pubmed/28115948
http://dx.doi.org/10.1155/2016/8158712
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author Lopez, Anna Lena
Raguindin, Peter Francis N.
Silvestre, Maria Asuncion
Fabay, Xenia Cathrine J.
Vinarao, Ariel B.
Manalastas, Ricardo
author_facet Lopez, Anna Lena
Raguindin, Peter Francis N.
Silvestre, Maria Asuncion
Fabay, Xenia Cathrine J.
Vinarao, Ariel B.
Manalastas, Ricardo
author_sort Lopez, Anna Lena
collection PubMed
description Background. As part of regional elimination efforts, rubella-containing vaccines (RCV) have recently been introduced in the Philippines, yet the true burden of rubella and congenital rubella syndrome (CRS) in the country is largely unknown. Objective. To provide baseline information on rubella and CRS prior to routine vaccine introduction in the Philippines. Methods. We conducted a systematic literature review on rubella and CRS in the Philippines, including a cross-sectional study conducted in 2002 among 383 pregnant women attending the obstetric outpatient clinic of the Philippine General Hospital to assess rubella susceptibility of women of childbearing age. Results. 15 locally published and unpublished studies were reviewed. Susceptibility to rubella among women of childbearing age was higher in rural communities. Retrospective reviews revealed congenital heart diseases, cataracts, and hearing impairments to be most common presentations in children of CRS. In the cross-sectional study, 59 (15.4%) of the 383 pregnant women enrolled were seronegative for rubella IgG. Conclusion. Similar to other countries introducing RCV, it was only recently that surveillance for rubella has been established. Previous studies show substantial disabilities due to CRS and a substantial proportion of susceptible women who are at risk for having babies affected with CRS. Establishment of CRS surveillance and enhanced awareness on rubella case detection should be prioritized.
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spelling pubmed-52253392017-01-23 Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review Lopez, Anna Lena Raguindin, Peter Francis N. Silvestre, Maria Asuncion Fabay, Xenia Cathrine J. Vinarao, Ariel B. Manalastas, Ricardo Int J Pediatr Review Article Background. As part of regional elimination efforts, rubella-containing vaccines (RCV) have recently been introduced in the Philippines, yet the true burden of rubella and congenital rubella syndrome (CRS) in the country is largely unknown. Objective. To provide baseline information on rubella and CRS prior to routine vaccine introduction in the Philippines. Methods. We conducted a systematic literature review on rubella and CRS in the Philippines, including a cross-sectional study conducted in 2002 among 383 pregnant women attending the obstetric outpatient clinic of the Philippine General Hospital to assess rubella susceptibility of women of childbearing age. Results. 15 locally published and unpublished studies were reviewed. Susceptibility to rubella among women of childbearing age was higher in rural communities. Retrospective reviews revealed congenital heart diseases, cataracts, and hearing impairments to be most common presentations in children of CRS. In the cross-sectional study, 59 (15.4%) of the 383 pregnant women enrolled were seronegative for rubella IgG. Conclusion. Similar to other countries introducing RCV, it was only recently that surveillance for rubella has been established. Previous studies show substantial disabilities due to CRS and a substantial proportion of susceptible women who are at risk for having babies affected with CRS. Establishment of CRS surveillance and enhanced awareness on rubella case detection should be prioritized. Hindawi Publishing Corporation 2016 2016-12-28 /pmc/articles/PMC5225339/ /pubmed/28115948 http://dx.doi.org/10.1155/2016/8158712 Text en Copyright © 2016 Anna Lena Lopez et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lopez, Anna Lena
Raguindin, Peter Francis N.
Silvestre, Maria Asuncion
Fabay, Xenia Cathrine J.
Vinarao, Ariel B.
Manalastas, Ricardo
Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review
title Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review
title_full Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review
title_fullStr Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review
title_full_unstemmed Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review
title_short Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review
title_sort rubella and congenital rubella syndrome in the philippines: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225339/
https://www.ncbi.nlm.nih.gov/pubmed/28115948
http://dx.doi.org/10.1155/2016/8158712
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