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Advances in urethral stricture management
Urethral stricture/stenosis is a narrowing of the urethral lumen. These conditions greatly impact the health and quality of life of patients. Management of urethral strictures/stenosis is complex and requires careful evaluation. The treatment options for urethral stricture vary in their success rate...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225410/ https://www.ncbi.nlm.nih.gov/pubmed/28105329 http://dx.doi.org/10.12688/f1000research.9741.1 |
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author | Gallegos, Maxx A. Santucci, Richard A. |
author_facet | Gallegos, Maxx A. Santucci, Richard A. |
author_sort | Gallegos, Maxx A. |
collection | PubMed |
description | Urethral stricture/stenosis is a narrowing of the urethral lumen. These conditions greatly impact the health and quality of life of patients. Management of urethral strictures/stenosis is complex and requires careful evaluation. The treatment options for urethral stricture vary in their success rates. Urethral dilation and internal urethrotomy are the most commonly performed procedures but carry the lowest chance for long-term success (0–9%). Urethroplasty has a much higher chance of success (85–90%) and is considered the gold-standard treatment. The most common urethroplasty techniques are excision and primary anastomosis and graft onlay urethroplasty. Anastomotic urethroplasty and graft urethroplasty have similar long-term success rates, although long-term data have yet to confirm equal efficacy. Anastomotic urethroplasty may have higher rates of sexual dysfunction. Posterior urethral stenosis is typically caused by previous urologic surgery. It is treated endoscopically with radial incisions. The use of mitomycin C may decrease recurrence. An exciting area of research is tissue engineering and scar modulation to augment stricture treatment. These include the use of acellular matrices or tissue-engineered buccal mucosa to produce grafting material for urethroplasty. Other experimental strategies aim to prevent scar formation altogether. |
format | Online Article Text |
id | pubmed-5225410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-52254102017-01-18 Advances in urethral stricture management Gallegos, Maxx A. Santucci, Richard A. F1000Res Review Urethral stricture/stenosis is a narrowing of the urethral lumen. These conditions greatly impact the health and quality of life of patients. Management of urethral strictures/stenosis is complex and requires careful evaluation. The treatment options for urethral stricture vary in their success rates. Urethral dilation and internal urethrotomy are the most commonly performed procedures but carry the lowest chance for long-term success (0–9%). Urethroplasty has a much higher chance of success (85–90%) and is considered the gold-standard treatment. The most common urethroplasty techniques are excision and primary anastomosis and graft onlay urethroplasty. Anastomotic urethroplasty and graft urethroplasty have similar long-term success rates, although long-term data have yet to confirm equal efficacy. Anastomotic urethroplasty may have higher rates of sexual dysfunction. Posterior urethral stenosis is typically caused by previous urologic surgery. It is treated endoscopically with radial incisions. The use of mitomycin C may decrease recurrence. An exciting area of research is tissue engineering and scar modulation to augment stricture treatment. These include the use of acellular matrices or tissue-engineered buccal mucosa to produce grafting material for urethroplasty. Other experimental strategies aim to prevent scar formation altogether. F1000Research 2016-12-23 /pmc/articles/PMC5225410/ /pubmed/28105329 http://dx.doi.org/10.12688/f1000research.9741.1 Text en Copyright: © 2016 Gallegos MA and Santucci RA http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Gallegos, Maxx A. Santucci, Richard A. Advances in urethral stricture management |
title | Advances in urethral stricture management |
title_full | Advances in urethral stricture management |
title_fullStr | Advances in urethral stricture management |
title_full_unstemmed | Advances in urethral stricture management |
title_short | Advances in urethral stricture management |
title_sort | advances in urethral stricture management |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225410/ https://www.ncbi.nlm.nih.gov/pubmed/28105329 http://dx.doi.org/10.12688/f1000research.9741.1 |
work_keys_str_mv | AT gallegosmaxxa advancesinurethralstricturemanagement AT santucciricharda advancesinurethralstricturemanagement |