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Neutrophil elastase cleavage of the gC1q domain impairs the EMILIN1-α4β1 integrin interaction, cell adhesion and anti-proliferative activity

The extracellular matrix glycoprotein EMILIN1 exerts a wide range of functions mainly associated with its gC1q domain. Besides providing functional significance for adhesion and migration, the direct interaction between α4β1 integrin and EMILIN1-gC1q regulates cell proliferation, transducing net ant...

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Detalles Bibliográficos
Autores principales:	Maiorani, Orlando, Pivetta, Eliana, Capuano, Alessandra, Modica, Teresa Maria Elisa, Wassermann, Bruna, Bucciotti, Francesco, Colombatti, Alfonso, Doliana, Roberto, Spessotto, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225433/ https://www.ncbi.nlm.nih.gov/pubmed/28074935 http://dx.doi.org/10.1038/srep39974

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