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A reduced mechanical model for cAMP-modulated gating in HCN channels

We developed an in silico mechanical model to analyze the process of cAMP-induced conformational modulations in hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which conduct cations across the membrane of mammalian heart and brain cells. The structural analysis reveals a quaterna...

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Detalles Bibliográficos
Autores principales:	Weißgraeber, Stephanie, Saponaro, Andrea, Thiel, Gerhard, Hamacher, Kay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225470/ https://www.ncbi.nlm.nih.gov/pubmed/28074902 http://dx.doi.org/10.1038/srep40168

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