Crystal Structure of StnA for the Biosynthesis of Antitumor Drug Streptonigrin Reveals a Unique Substrate Binding Mode

Streptonigrin methylesterase A (StnA) is one of the tailoring enzymes that modify the aminoquinone skeleton in the biosynthesis pathway of Streptomyces species. Although StnA has no significant sequence homology with the reported α/β-fold hydrolases, it shows typical hydrolytic activity in vivo and...

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Detalles Bibliográficos
Autores principales: Qian, Tianle, Wo, Jing, Zhang, Yan, Song, Quanwei, Feng, Guoqiang, Luo, Ray, Lin, Shuangjin, Wu, Geng, Chen, Hai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225493/
https://www.ncbi.nlm.nih.gov/pubmed/28074848
http://dx.doi.org/10.1038/srep40254

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