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Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis
BACKGROUND: People use khat (Catha edulis) for its pleasant stimulant effect of physical activity, consciousness, motor, and mental functions. Although there are reports assessing the effect of khat on memory, there was no study based on formal systematic review and meta-analysis. OBJECTIVE: We have...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225718/ https://www.ncbi.nlm.nih.gov/pubmed/28149078 http://dx.doi.org/10.4103/0976-3147.193524 |
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author | Berihu, Birhane Alem Asfeha, Gebrekidan Gebregzabher Welderufael, Abadi Leul Debeb, Yared Godefa Zelelow, Yibrah Berhe Beyene, Hafte Assefa |
author_facet | Berihu, Birhane Alem Asfeha, Gebrekidan Gebregzabher Welderufael, Abadi Leul Debeb, Yared Godefa Zelelow, Yibrah Berhe Beyene, Hafte Assefa |
author_sort | Berihu, Birhane Alem |
collection | PubMed |
description | BACKGROUND: People use khat (Catha edulis) for its pleasant stimulant effect of physical activity, consciousness, motor, and mental functions. Although there are reports assessing the effect of khat on memory, there was no study based on formal systematic review and meta-analysis. OBJECTIVE: We have therefore conducted this meta-analysis to determine the level of evidence for the effect of khat (C. edulis Forsk) on memory discrepancy. METHODS: MEDLINE, Cochrane Library, PubMed, Academic Search Complete, SPORTDiscus, ScienceDirect, Scopus, Web of Science, and Google Scholar were searched to retrieve the papers for this review. Keywords utilized across database search were khat, cat, chat, long-term memory, short-term memory, memory deficit, randomized control trial, and cross-sectional survey. The search was limited to studies in humans and rodents; published in English language. RESULT: Finding of various studies included in our meta-analysis showed that the effect of acute, and subchronic exposure to khat showed that short-term memory appears to be affected depending on the duration of exposure. However, does not have any effect on long-term memory. CONCLUSION: Although a number of studies regarding the current topic are limited, the evidenced showed that khat (C. edulis) induced memory discrepancy. |
format | Online Article Text |
id | pubmed-5225718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-52257182017-02-01 Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis Berihu, Birhane Alem Asfeha, Gebrekidan Gebregzabher Welderufael, Abadi Leul Debeb, Yared Godefa Zelelow, Yibrah Berhe Beyene, Hafte Assefa J Neurosci Rural Pract Original Article BACKGROUND: People use khat (Catha edulis) for its pleasant stimulant effect of physical activity, consciousness, motor, and mental functions. Although there are reports assessing the effect of khat on memory, there was no study based on formal systematic review and meta-analysis. OBJECTIVE: We have therefore conducted this meta-analysis to determine the level of evidence for the effect of khat (C. edulis Forsk) on memory discrepancy. METHODS: MEDLINE, Cochrane Library, PubMed, Academic Search Complete, SPORTDiscus, ScienceDirect, Scopus, Web of Science, and Google Scholar were searched to retrieve the papers for this review. Keywords utilized across database search were khat, cat, chat, long-term memory, short-term memory, memory deficit, randomized control trial, and cross-sectional survey. The search was limited to studies in humans and rodents; published in English language. RESULT: Finding of various studies included in our meta-analysis showed that the effect of acute, and subchronic exposure to khat showed that short-term memory appears to be affected depending on the duration of exposure. However, does not have any effect on long-term memory. CONCLUSION: Although a number of studies regarding the current topic are limited, the evidenced showed that khat (C. edulis) induced memory discrepancy. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5225718/ /pubmed/28149078 http://dx.doi.org/10.4103/0976-3147.193524 Text en Copyright: © Journal of Neurosciences in Rural Practice http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Berihu, Birhane Alem Asfeha, Gebrekidan Gebregzabher Welderufael, Abadi Leul Debeb, Yared Godefa Zelelow, Yibrah Berhe Beyene, Hafte Assefa Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis |
title | Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis |
title_full | Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis |
title_fullStr | Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis |
title_full_unstemmed | Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis |
title_short | Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis |
title_sort | toxic effect of khat (catha edulis) on memory: systematic review and meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225718/ https://www.ncbi.nlm.nih.gov/pubmed/28149078 http://dx.doi.org/10.4103/0976-3147.193524 |
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