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Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis

BACKGROUND: People use khat (Catha edulis) for its pleasant stimulant effect of physical activity, consciousness, motor, and mental functions. Although there are reports assessing the effect of khat on memory, there was no study based on formal systematic review and meta-analysis. OBJECTIVE: We have...

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Autores principales: Berihu, Birhane Alem, Asfeha, Gebrekidan Gebregzabher, Welderufael, Abadi Leul, Debeb, Yared Godefa, Zelelow, Yibrah Berhe, Beyene, Hafte Assefa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225718/
https://www.ncbi.nlm.nih.gov/pubmed/28149078
http://dx.doi.org/10.4103/0976-3147.193524
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author Berihu, Birhane Alem
Asfeha, Gebrekidan Gebregzabher
Welderufael, Abadi Leul
Debeb, Yared Godefa
Zelelow, Yibrah Berhe
Beyene, Hafte Assefa
author_facet Berihu, Birhane Alem
Asfeha, Gebrekidan Gebregzabher
Welderufael, Abadi Leul
Debeb, Yared Godefa
Zelelow, Yibrah Berhe
Beyene, Hafte Assefa
author_sort Berihu, Birhane Alem
collection PubMed
description BACKGROUND: People use khat (Catha edulis) for its pleasant stimulant effect of physical activity, consciousness, motor, and mental functions. Although there are reports assessing the effect of khat on memory, there was no study based on formal systematic review and meta-analysis. OBJECTIVE: We have therefore conducted this meta-analysis to determine the level of evidence for the effect of khat (C. edulis Forsk) on memory discrepancy. METHODS: MEDLINE, Cochrane Library, PubMed, Academic Search Complete, SPORTDiscus, ScienceDirect, Scopus, Web of Science, and Google Scholar were searched to retrieve the papers for this review. Keywords utilized across database search were khat, cat, chat, long-term memory, short-term memory, memory deficit, randomized control trial, and cross-sectional survey. The search was limited to studies in humans and rodents; published in English language. RESULT: Finding of various studies included in our meta-analysis showed that the effect of acute, and subchronic exposure to khat showed that short-term memory appears to be affected depending on the duration of exposure. However, does not have any effect on long-term memory. CONCLUSION: Although a number of studies regarding the current topic are limited, the evidenced showed that khat (C. edulis) induced memory discrepancy.
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spelling pubmed-52257182017-02-01 Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis Berihu, Birhane Alem Asfeha, Gebrekidan Gebregzabher Welderufael, Abadi Leul Debeb, Yared Godefa Zelelow, Yibrah Berhe Beyene, Hafte Assefa J Neurosci Rural Pract Original Article BACKGROUND: People use khat (Catha edulis) for its pleasant stimulant effect of physical activity, consciousness, motor, and mental functions. Although there are reports assessing the effect of khat on memory, there was no study based on formal systematic review and meta-analysis. OBJECTIVE: We have therefore conducted this meta-analysis to determine the level of evidence for the effect of khat (C. edulis Forsk) on memory discrepancy. METHODS: MEDLINE, Cochrane Library, PubMed, Academic Search Complete, SPORTDiscus, ScienceDirect, Scopus, Web of Science, and Google Scholar were searched to retrieve the papers for this review. Keywords utilized across database search were khat, cat, chat, long-term memory, short-term memory, memory deficit, randomized control trial, and cross-sectional survey. The search was limited to studies in humans and rodents; published in English language. RESULT: Finding of various studies included in our meta-analysis showed that the effect of acute, and subchronic exposure to khat showed that short-term memory appears to be affected depending on the duration of exposure. However, does not have any effect on long-term memory. CONCLUSION: Although a number of studies regarding the current topic are limited, the evidenced showed that khat (C. edulis) induced memory discrepancy. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5225718/ /pubmed/28149078 http://dx.doi.org/10.4103/0976-3147.193524 Text en Copyright: © Journal of Neurosciences in Rural Practice http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Berihu, Birhane Alem
Asfeha, Gebrekidan Gebregzabher
Welderufael, Abadi Leul
Debeb, Yared Godefa
Zelelow, Yibrah Berhe
Beyene, Hafte Assefa
Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis
title Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis
title_full Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis
title_fullStr Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis
title_full_unstemmed Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis
title_short Toxic effect of khat (Catha edulis) on memory: Systematic review and meta-analysis
title_sort toxic effect of khat (catha edulis) on memory: systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225718/
https://www.ncbi.nlm.nih.gov/pubmed/28149078
http://dx.doi.org/10.4103/0976-3147.193524
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