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Autonomic dysfunction: A comparative study of patients with Alzheimer's and frontotemporal dementia – A pilot study

INTRODUCTION: In frontotemporal dementia (FTD) and Alzheimer's disease (AD), central autonomic structures get affected early. An insight into autonomic functions in these patients is likely to be of diagnostic importance and thus help in prognosticating and also probably explain unexplained sud...

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Autores principales: Issac, Thomas Gregor, Chandra, Sadanandavalli Retnaswami, Gupta, Neelesh, Rukmani, Malligurki Raghurama, Deepika, S., Sathyaprabha, T. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225730/
https://www.ncbi.nlm.nih.gov/pubmed/28149088
http://dx.doi.org/10.4103/0976-3147.193545
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author Issac, Thomas Gregor
Chandra, Sadanandavalli Retnaswami
Gupta, Neelesh
Rukmani, Malligurki Raghurama
Deepika, S.
Sathyaprabha, T. N.
author_facet Issac, Thomas Gregor
Chandra, Sadanandavalli Retnaswami
Gupta, Neelesh
Rukmani, Malligurki Raghurama
Deepika, S.
Sathyaprabha, T. N.
author_sort Issac, Thomas Gregor
collection PubMed
description INTRODUCTION: In frontotemporal dementia (FTD) and Alzheimer's disease (AD), central autonomic structures get affected early. An insight into autonomic functions in these patients is likely to be of diagnostic importance and thus help in prognosticating and also probably explain unexplained sudden death in some of these patients. OBJECTIVES: The objective of this study is to identify autonomic dysfunction prevailing in patients. Then, if there is dysfunction, is the pattern same or different in these two conditions. And if different it will serve as an additional biomarker for specific diagnosis. PATIENTS AND METHODS: There were 25 patients and 25 controls and six patients and three controls in AD and FTD groups, respectively. The participants who were recruited were assessed for heart rate variability and conventional cardiac autonomic function testing. The parameters were analyzed using LabChart version 7 software and compared with control population using appropriate statistical methods using SPSS version 22 software. RESULTS: The mean overall total power was low in the FTD group (P < 0.001), and there was significant reduction in the standard deviation of normal-to-normal intervals and root mean square of successive differences (P < 0.001) with elevated sympathovagal balance in the FTD group (P = 0.04). Patients with AD also showed sympathetic dominance, but there was in addition parasympathetic suppression unlike in the FTD group. CONCLUSION: This study reveals autonomic dysfunction in patients with FTD and AD. Both conditions show sympathetic dominance, probably consecutive to the involvement of central autonomic regulatory structures as a shared domain. It remains to be confirmed if these findings are the cause or effect of neurodegeneration and might open up newer territories of research based on the causal role of neurotransmitters in these regions and thus lead to novel therapeutic options such as yoga. The presence of parasympathetic suppression in AD in addition helps differentiate these two conditions.
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spelling pubmed-52257302017-02-01 Autonomic dysfunction: A comparative study of patients with Alzheimer's and frontotemporal dementia – A pilot study Issac, Thomas Gregor Chandra, Sadanandavalli Retnaswami Gupta, Neelesh Rukmani, Malligurki Raghurama Deepika, S. Sathyaprabha, T. N. J Neurosci Rural Pract Original Article INTRODUCTION: In frontotemporal dementia (FTD) and Alzheimer's disease (AD), central autonomic structures get affected early. An insight into autonomic functions in these patients is likely to be of diagnostic importance and thus help in prognosticating and also probably explain unexplained sudden death in some of these patients. OBJECTIVES: The objective of this study is to identify autonomic dysfunction prevailing in patients. Then, if there is dysfunction, is the pattern same or different in these two conditions. And if different it will serve as an additional biomarker for specific diagnosis. PATIENTS AND METHODS: There were 25 patients and 25 controls and six patients and three controls in AD and FTD groups, respectively. The participants who were recruited were assessed for heart rate variability and conventional cardiac autonomic function testing. The parameters were analyzed using LabChart version 7 software and compared with control population using appropriate statistical methods using SPSS version 22 software. RESULTS: The mean overall total power was low in the FTD group (P < 0.001), and there was significant reduction in the standard deviation of normal-to-normal intervals and root mean square of successive differences (P < 0.001) with elevated sympathovagal balance in the FTD group (P = 0.04). Patients with AD also showed sympathetic dominance, but there was in addition parasympathetic suppression unlike in the FTD group. CONCLUSION: This study reveals autonomic dysfunction in patients with FTD and AD. Both conditions show sympathetic dominance, probably consecutive to the involvement of central autonomic regulatory structures as a shared domain. It remains to be confirmed if these findings are the cause or effect of neurodegeneration and might open up newer territories of research based on the causal role of neurotransmitters in these regions and thus lead to novel therapeutic options such as yoga. The presence of parasympathetic suppression in AD in addition helps differentiate these two conditions. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5225730/ /pubmed/28149088 http://dx.doi.org/10.4103/0976-3147.193545 Text en Copyright: © Journal of Neurosciences in Rural Practice http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Issac, Thomas Gregor
Chandra, Sadanandavalli Retnaswami
Gupta, Neelesh
Rukmani, Malligurki Raghurama
Deepika, S.
Sathyaprabha, T. N.
Autonomic dysfunction: A comparative study of patients with Alzheimer's and frontotemporal dementia – A pilot study
title Autonomic dysfunction: A comparative study of patients with Alzheimer's and frontotemporal dementia – A pilot study
title_full Autonomic dysfunction: A comparative study of patients with Alzheimer's and frontotemporal dementia – A pilot study
title_fullStr Autonomic dysfunction: A comparative study of patients with Alzheimer's and frontotemporal dementia – A pilot study
title_full_unstemmed Autonomic dysfunction: A comparative study of patients with Alzheimer's and frontotemporal dementia – A pilot study
title_short Autonomic dysfunction: A comparative study of patients with Alzheimer's and frontotemporal dementia – A pilot study
title_sort autonomic dysfunction: a comparative study of patients with alzheimer's and frontotemporal dementia – a pilot study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225730/
https://www.ncbi.nlm.nih.gov/pubmed/28149088
http://dx.doi.org/10.4103/0976-3147.193545
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