Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications

Conventional in vitro human hepatic models for drug testing are based on the use of standard cell lines derived from hepatomas or primary human hepatocytes (PHHs). Limited availability, interdonor functional variability and early phenotypic alterations in PHHs restrict their use, whilst standard cel...

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Detalles Bibliográficos
Autores principales: Nelson, Leonard J., Morgan, Katie, Treskes, Philipp, Samuel, Kay, Henderson, Catherine J., LeBled, Claire, Homer, Natalie, Grant, M. Helen, Hayes, Peter C., Plevris, John N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225883/
https://www.ncbi.nlm.nih.gov/pubmed/27285124
http://dx.doi.org/10.1111/bcpt.12631

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