AmBisome Induced Avascular Necrosis of the Alae of the Nose of a very young girl suffering from Kala‐azar – a Case Report

Although liposomal amphotericin B (AmBisome) is considered as the first‐line treatment for New Kala‐azar, there is not enough evidence on the dosage formulation in children and its effect on them. Being considered as the safest drug for treatment of Kala‐azar, this case of AmBisome‐induced avascular...

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Autores principales: Maruf, Shomik, Nath, Proggananda, Aktar, Fatima, Basher, Ariful
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226290/
https://www.ncbi.nlm.nih.gov/pubmed/28097002
http://dx.doi.org/10.1002/prp2.269
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author Maruf, Shomik
Nath, Proggananda
Aktar, Fatima
Basher, Ariful
author_facet Maruf, Shomik
Nath, Proggananda
Aktar, Fatima
Basher, Ariful
author_sort Maruf, Shomik
collection PubMed
description Although liposomal amphotericin B (AmBisome) is considered as the first‐line treatment for New Kala‐azar, there is not enough evidence on the dosage formulation in children and its effect on them. Being considered as the safest drug for treatment of Kala‐azar, this case of AmBisome‐induced avascular necrosis now gives rise to the question; whether it is actually safe enough and if a dosage modification is needed in case of children. This so far, to the best of our knowledge, is the first instance of such severe adverse event due to AmBisome administration.
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spelling pubmed-52262902017-01-17 AmBisome Induced Avascular Necrosis of the Alae of the Nose of a very young girl suffering from Kala‐azar – a Case Report Maruf, Shomik Nath, Proggananda Aktar, Fatima Basher, Ariful Pharmacol Res Perspect Original Articles Although liposomal amphotericin B (AmBisome) is considered as the first‐line treatment for New Kala‐azar, there is not enough evidence on the dosage formulation in children and its effect on them. Being considered as the safest drug for treatment of Kala‐azar, this case of AmBisome‐induced avascular necrosis now gives rise to the question; whether it is actually safe enough and if a dosage modification is needed in case of children. This so far, to the best of our knowledge, is the first instance of such severe adverse event due to AmBisome administration. John Wiley and Sons Inc. 2016-10-21 /pmc/articles/PMC5226290/ /pubmed/28097002 http://dx.doi.org/10.1002/prp2.269 Text en © 2016 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Maruf, Shomik
Nath, Proggananda
Aktar, Fatima
Basher, Ariful
AmBisome Induced Avascular Necrosis of the Alae of the Nose of a very young girl suffering from Kala‐azar – a Case Report
title AmBisome Induced Avascular Necrosis of the Alae of the Nose of a very young girl suffering from Kala‐azar – a Case Report
title_full AmBisome Induced Avascular Necrosis of the Alae of the Nose of a very young girl suffering from Kala‐azar – a Case Report
title_fullStr AmBisome Induced Avascular Necrosis of the Alae of the Nose of a very young girl suffering from Kala‐azar – a Case Report
title_full_unstemmed AmBisome Induced Avascular Necrosis of the Alae of the Nose of a very young girl suffering from Kala‐azar – a Case Report
title_short AmBisome Induced Avascular Necrosis of the Alae of the Nose of a very young girl suffering from Kala‐azar – a Case Report
title_sort ambisome induced avascular necrosis of the alae of the nose of a very young girl suffering from kala‐azar – a case report
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226290/
https://www.ncbi.nlm.nih.gov/pubmed/28097002
http://dx.doi.org/10.1002/prp2.269
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