Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells

Recent evidence suggest that a β-glucan derived from mushroom Schizophyllan(SPG) complexed with a humanized TLR9 agonistic CpG DNA, K3 (K3-SPG) is a promising vaccine adjuvant that induces robust CD8 T cell responses to co-administered antigen. However, it has not been investigated whether K3-SPG al...

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Detalles Bibliográficos
Autores principales: Kitahata, Yuji, Kanuma, Tomohiro, Hayashi, Masayuki, Kobayashi, Nobuyoshi, Ozasa, Koji, Kusakabe, Takato, Temizoz, Burcu, Kuroda, Etsushi, Yamaue, Hiroki, Coban, Cevayir, Yamamoto, Takuya, Kobiyama, Kouji, Aoshi, Taiki, Ishii, Ken J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226476/
https://www.ncbi.nlm.nih.gov/pubmed/27384490
http://dx.doi.org/10.18632/oncotarget.10379

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