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PIP(3)-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans

Class-I phosphatidylinositol 3-kinase (PI3K(I)) converts phosphatidylinositol 4,5-bisphosphate (PIP(2)) to phosphatidylinositol 3,4,5-triphosphate (PIP(3)). PIP(3) comprises two fatty-acid chains that embed in lipid-bilayer membranes, joined by glycerol to inositol triphosphate. Proteins with domain...

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Detalles Bibliográficos
Autores principales:	Ayyadevara, Srinivas, Balasubramaniam, Meenakshisundaram, Johnson, Jay, Alla, Ramani, Mackintosh, Samuel G., Shmookler Reis, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226477/ https://www.ncbi.nlm.nih.gov/pubmed/27429199 http://dx.doi.org/10.18632/oncotarget.10549

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