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Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

Apoptosis is deregulated in most, if not all, cancers, including hematological malignancies. Smac mimetics that antagonize Inhibitor of Apoptosis (IAP) proteins have so far largely been investigated in acute myeloid leukemia (AML) cell lines; however, little is yet known on the therapeutic potential...

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Detalles Bibliográficos
Autores principales:	Lueck, Sonja C., Russ, Annika C., Botzenhardt, Ursula, Schlenk, Richard F., Zobel, Kerry, Deshayes, Kurt, Vucic, Domagoj, Döhner, Hartmut, Döhner, Konstanze, Fulda, Simone, Bullinger, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226527/ https://www.ncbi.nlm.nih.gov/pubmed/27385100 http://dx.doi.org/10.18632/oncotarget.10390

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