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Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer

AIMS: To evaluate the clinical significance of multiple serum tumor markers (TMs) in the diagnosis of gastric cancer (GC) and establish an accurate discriminant equation to identify the presence of GC. RESULTS: The serum levels of CEA, CA19-9 and CA72-4 were higher in the GC group than in the contro...

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Autores principales: Liang, Yao, Wang, Wei, Fang, Cheng, Raj, Seeruttun Sharvesh, Hu, Wan-Ming, Li, Qi-Wen, Zhou, Zhi-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226529/
https://www.ncbi.nlm.nih.gov/pubmed/27385101
http://dx.doi.org/10.18632/oncotarget.10391
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author Liang, Yao
Wang, Wei
Fang, Cheng
Raj, Seeruttun Sharvesh
Hu, Wan-Ming
Li, Qi-Wen
Zhou, Zhi-Wei
author_facet Liang, Yao
Wang, Wei
Fang, Cheng
Raj, Seeruttun Sharvesh
Hu, Wan-Ming
Li, Qi-Wen
Zhou, Zhi-Wei
author_sort Liang, Yao
collection PubMed
description AIMS: To evaluate the clinical significance of multiple serum tumor markers (TMs) in the diagnosis of gastric cancer (GC) and establish an accurate discriminant equation to identify the presence of GC. RESULTS: The serum levels of CEA, CA19-9 and CA72-4 were higher in the GC group than in the control group (P < 0.005). The sensitivity of CEA, CA19-9 and CA72-4 in the diagnosis of GC was 20.1–27.6% individually and increased to 48.2% when they were considered in combination. By using the optimal cut-off value, the sensitivity of CEA, CA19-9 and CA72-4 for the diagnosis of GC was improved but remained unsatisfactory. In addition, we developed the equation Y = −2.185 − 0.015 X1 + 0.180 X2 + 1.226 X3 + 1.505 X4 + 2.749 X5 (X1 = Age, X2 = Sex, X3 =CEA, X4 = CA19-9 and X5 = CA72-4) to predict the presence of GC. This has better accuracy and diagnostic efficiency compared to the combination of TMs. METHODS: Serum carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9)and cancer antigen 72-4 (CA72-4) levels were measured in a total of 2288 patients with GC and 1869 healthy volunteers or patients with benign gastric diseases. We established a diagnostic equation using a portion of the data (training set), and validate its accuracy using the other portion of the data (testing set). CONCLUSIONS: The diagnostic equation increases the accuracy rate for the diagnosis of GC and will be helpful in the clinic.
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spelling pubmed-52265292017-01-18 Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer Liang, Yao Wang, Wei Fang, Cheng Raj, Seeruttun Sharvesh Hu, Wan-Ming Li, Qi-Wen Zhou, Zhi-Wei Oncotarget Research Paper AIMS: To evaluate the clinical significance of multiple serum tumor markers (TMs) in the diagnosis of gastric cancer (GC) and establish an accurate discriminant equation to identify the presence of GC. RESULTS: The serum levels of CEA, CA19-9 and CA72-4 were higher in the GC group than in the control group (P < 0.005). The sensitivity of CEA, CA19-9 and CA72-4 in the diagnosis of GC was 20.1–27.6% individually and increased to 48.2% when they were considered in combination. By using the optimal cut-off value, the sensitivity of CEA, CA19-9 and CA72-4 for the diagnosis of GC was improved but remained unsatisfactory. In addition, we developed the equation Y = −2.185 − 0.015 X1 + 0.180 X2 + 1.226 X3 + 1.505 X4 + 2.749 X5 (X1 = Age, X2 = Sex, X3 =CEA, X4 = CA19-9 and X5 = CA72-4) to predict the presence of GC. This has better accuracy and diagnostic efficiency compared to the combination of TMs. METHODS: Serum carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9)and cancer antigen 72-4 (CA72-4) levels were measured in a total of 2288 patients with GC and 1869 healthy volunteers or patients with benign gastric diseases. We established a diagnostic equation using a portion of the data (training set), and validate its accuracy using the other portion of the data (testing set). CONCLUSIONS: The diagnostic equation increases the accuracy rate for the diagnosis of GC and will be helpful in the clinic. Impact Journals LLC 2016-07-02 /pmc/articles/PMC5226529/ /pubmed/27385101 http://dx.doi.org/10.18632/oncotarget.10391 Text en Copyright: © 2016 Liang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Liang, Yao
Wang, Wei
Fang, Cheng
Raj, Seeruttun Sharvesh
Hu, Wan-Ming
Li, Qi-Wen
Zhou, Zhi-Wei
Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer
title Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer
title_full Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer
title_fullStr Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer
title_full_unstemmed Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer
title_short Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer
title_sort clinical significance and diagnostic value of serum cea, ca19-9 and ca72-4 in patients with gastric cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226529/
https://www.ncbi.nlm.nih.gov/pubmed/27385101
http://dx.doi.org/10.18632/oncotarget.10391
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