Cargando…

Elevated expression of the IGF2 mRNA binding protein 2 (IGF2BP2/IMP2) is linked to short survival and metastasis in esophageal adenocarcinoma

Esophageal adenocarcinoma (EAC) represents the sixth leading cause of cancer-related deaths and develops in Barret's esophagus affected tissues. The IGF2 mRNA binding protein IMP2/IGF2BP2/p62 was originally identified as an autoantigen in hepatocellular carcinoma. Aim of this study was to inves...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barghash, Ahmad, Golob-Schwarzl, Nicole, Helms, Volkhard, Haybaeck, Johannes, Kessler, Sonja M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226544/ https://www.ncbi.nlm.nih.gov/pubmed/27391348 http://dx.doi.org/10.18632/oncotarget.10439

Ejemplares similares

The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer
por: Dahlem, Charlotte, et al.
Publicado: (2019)

IMP2/IGF2BP2 expression, but not IMP1 and IMP3, predicts poor outcome in patients and high tumor growth rate in xenograft models of gallbladder cancer
por: Kessler, Sonja M., et al.
Publicado: (2017)

The insulin-like growth factor 2 (IGF2) mRNA-binding protein p62/IGF2BP2-2 as a promoter of NAFLD and HCC?
por: Simon, Yvette, et al.
Publicado: (2014)

IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis
por: Czepukojc, Beate, et al.
Publicado: (2019)

IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype
por: Kessler, S M, et al.
Publicado: (2015)

IGF2BP3 (IMP3) expression in angiosarcoma, epithelioid hemangioendothelioma, and benign vascular lesions
por: Okabayshi, Misuzu, et al.
Publicado: (2020)

Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability
por: Samuels, Tamsin J, et al.
Publicado: (2020)

RNA‐Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation
por: Liu, Hong‐Bin, et al.
Publicado: (2019)

Targeting IGF2BP3 in Cancer
por: Liu, Xin, et al.
Publicado: (2023)

Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk
por: Tang, Weifeng, et al.
Publicado: (2018)

A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer
por: Kendzia, Sandra, et al.
Publicado: (2023)

Identification of an IGF2BP2-Targeted Peptide for Near-Infrared Imaging of Esophageal Squamous Cell Carcinoma
por: Shu, Wenbin, et al.
Publicado: (2022)

Comment on: The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ
por: Schymik, Hanna S., et al.
Publicado: (2022)

Two Isoforms of the mRNA Binding Protein IGF2BP2 Are Generated by Alternative Translational Initiation
por: Le, Hang T. T., et al.
Publicado: (2012)

RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression
por: Regué, Laura, et al.
Publicado: (2021)

Expression of the cancer testis antigen IGF2BP3 in colorectal cancers; IGF2BP3 holds promise as a specific immunotherapy target
por: Shantha Kumara, HMC, et al.
Publicado: (2015)

IGF2BP2 Promotes Epithelial to Mesenchymal Transition and Metastasis through Stabilizing HMGA1 mRNA in Gastric Cancer
por: Ouyang, Jun, et al.
Publicado: (2022)

Elevated expression of the RNA-binding protein IGF2BP1 enhances the mRNA stability of INHBA to promote the invasion and migration of esophageal squamous cancer cells
por: Wang, Juan-Juan, et al.
Publicado: (2023)

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer
por: Huang, Xinwei, et al.
Publicado: (2018)

m(6)A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma
por: Fang, Han, et al.
Publicado: (2023)

Methylation in MIRLET7A3 Gene Induces the Expression of IGF-II and Its mRNA Binding Proteins IGF2BP-2 and 3 in Hepatocellular Carcinoma
por: Waly, Amr A., et al.
Publicado: (2019)

UBE2K regulated by IGF2BP3 promotes cell proliferation and stemness in pancreatic ductal adenocarcinoma
por: Fu, Wen, et al.
Publicado: (2023)

Evaluation of the Association of IGF2BP2 Variants With Type 2 Diabetes in French Caucasians
por: Duesing, Konsta, et al.
Publicado: (2008)

Tagged actin mRNA dysregulation in IGF2BP1 [Formula: see text] mice
por: Núñez, Leti, et al.
Publicado: (2022)

m(6)A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2‐mediated IGF1R mRNA stabilization
por: Lang, Chuandong, et al.
Publicado: (2021)

IGF2BP2 Polymorphisms Are Associated with Clinical Characteristics and Development of Oral Cancer
por: Chou, Chia-Hsuan, et al.
Publicado: (2020)

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader
por: Hu, Xiaoge, et al.
Publicado: (2019)

Role of IGF2BP3 in trophoblast cell invasion and migration
por: Li, W, et al.
Publicado: (2014)

Identification of IGF2BP3 as an Adverse Prognostic Biomarker of Gliomas
por: Sun, Chao, et al.
Publicado: (2021)

RNA-Binding Protein IGF2BP1 Associated With Prognosis and Immunotherapy Response in Lung Adenocarcinoma
por: Liu, JinFeng, et al.
Publicado: (2022)

Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation
por: Regué, Laura, et al.
Publicado: (2019)

FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2
por: Sun, Meige, et al.
Publicado: (2022)

IGF2BP3 as a potential tissue marker for the diagnosis of esophageal high-grade intraepithelial neoplasia
por: Zhang, Jingjing, et al.
Publicado: (2017)

Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes
por: Nfor, Oswald Ndi, et al.
Publicado: (2020)

Targeting IGF2BP2 Promotes Differentiation of Radioiodine Refractory Papillary Thyroid Cancer via Destabilizing RUNX2 mRNA
por: Sa, Ri, et al.
Publicado: (2022)

Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 (IMP3) is associated with chemoresistance and poor disease outcome in ovarian cancer
por: Hsu, K-F, et al.
Publicado: (2015)

Recognition of RNA N(6)-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation
por: Huang, Huilin, et al.
Publicado: (2018)

Integrative Analyses of mRNA Expression Profile Reveal the Involvement of IGF2BP1 in Chicken Adipogenesis
por: Chen, Jiahui, et al.
Publicado: (2019)

Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) overexpression in pancreatic ductal adenocarcinoma correlates with poor survival
por: Schaeffer, David F, et al.
Publicado: (2010)

The relationship between IGF2BP2 and PPARG polymorphisms and susceptibility to esophageal squamous-cell carcinomas in the eastern Chinese Han population
por: Qiu, Hao, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qbpkb80nf4893o1j5u1fa5lv2u