Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis

Cancer stem cells are associated with tumor recurrence. IKK is a protein kinase that is composed of IKKα, IKKβ, IKKγ. Herein, we demonstrate that IKKα plus IKKβ promoted and IKKγ inhibited liver cancer stem cell growth in vitro and in vivo. Mechanistically, IKKα plus IKKβ enhanced and IKKγ inhibited...

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Detalles Bibliográficos
Autores principales: An, Jiahui, Wu, Mengying, Xin, Xiaoru, Lin, Zhuojia, Li, Xiaonan, Zheng, Qidi, Gui, Xin, Li, Tianming, Pu, Hu, Li, Haiyan, Lu, Dongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226573/
https://www.ncbi.nlm.nih.gov/pubmed/27367027
http://dx.doi.org/10.18632/oncotarget.10321

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