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Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer
Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226593/ https://www.ncbi.nlm.nih.gov/pubmed/27391432 http://dx.doi.org/10.18632/oncotarget.10416 |
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author | Kong, Hui Wu, Ying Zhu, Mengou Zhai, Changwen Qian, Jing Gao, Xue Wang, Shuyang Hou, Yingyong Lu, Shaohua Zhu, Hongguang |
author_facet | Kong, Hui Wu, Ying Zhu, Mengou Zhai, Changwen Qian, Jing Gao, Xue Wang, Shuyang Hou, Yingyong Lu, Shaohua Zhu, Hongguang |
author_sort | Kong, Hui |
collection | PubMed |
description | Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with liver metastases and 57 stage I/II CRC specimens. The expression levels of four lncRNAs (GAS5, H19, MEG3 and Yiya) were significantly different between liver metastases and primary tumors of stage IV CRC patients. Furthermore, the high expression levels of GAS5 and Yiya were significantly associated with future occurrence of liver metastases in early stage CRC patients. Kaplan-Meier analysis showed that the high expression levels of GAS5 or Yiya were correlated with poor prognosis of early stage CRC patients (p = 0.0206 and 0.0005 for GAS5 and Yiya, respectively). Yiya expression was proved to be an independent prognostic indicator of colorectal liver metastases in a multivariate analysis (relative risk = 10.7; p < 0.0001). Our study revealed that GAS5 and Yiya were promising prognostic biomarkers of liver metastases for early stage CRC patients. |
format | Online Article Text |
id | pubmed-5226593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-52265932017-01-18 Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer Kong, Hui Wu, Ying Zhu, Mengou Zhai, Changwen Qian, Jing Gao, Xue Wang, Shuyang Hou, Yingyong Lu, Shaohua Zhu, Hongguang Oncotarget Research Paper Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with liver metastases and 57 stage I/II CRC specimens. The expression levels of four lncRNAs (GAS5, H19, MEG3 and Yiya) were significantly different between liver metastases and primary tumors of stage IV CRC patients. Furthermore, the high expression levels of GAS5 and Yiya were significantly associated with future occurrence of liver metastases in early stage CRC patients. Kaplan-Meier analysis showed that the high expression levels of GAS5 or Yiya were correlated with poor prognosis of early stage CRC patients (p = 0.0206 and 0.0005 for GAS5 and Yiya, respectively). Yiya expression was proved to be an independent prognostic indicator of colorectal liver metastases in a multivariate analysis (relative risk = 10.7; p < 0.0001). Our study revealed that GAS5 and Yiya were promising prognostic biomarkers of liver metastases for early stage CRC patients. Impact Journals LLC 2016-07-06 /pmc/articles/PMC5226593/ /pubmed/27391432 http://dx.doi.org/10.18632/oncotarget.10416 Text en Copyright: © 2016 Kong et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Kong, Hui Wu, Ying Zhu, Mengou Zhai, Changwen Qian, Jing Gao, Xue Wang, Shuyang Hou, Yingyong Lu, Shaohua Zhu, Hongguang Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer |
title | Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer |
title_full | Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer |
title_fullStr | Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer |
title_full_unstemmed | Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer |
title_short | Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer |
title_sort | long non-coding rnas: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226593/ https://www.ncbi.nlm.nih.gov/pubmed/27391432 http://dx.doi.org/10.18632/oncotarget.10416 |
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