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Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer

Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with...

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Autores principales: Kong, Hui, Wu, Ying, Zhu, Mengou, Zhai, Changwen, Qian, Jing, Gao, Xue, Wang, Shuyang, Hou, Yingyong, Lu, Shaohua, Zhu, Hongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226593/
https://www.ncbi.nlm.nih.gov/pubmed/27391432
http://dx.doi.org/10.18632/oncotarget.10416
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author Kong, Hui
Wu, Ying
Zhu, Mengou
Zhai, Changwen
Qian, Jing
Gao, Xue
Wang, Shuyang
Hou, Yingyong
Lu, Shaohua
Zhu, Hongguang
author_facet Kong, Hui
Wu, Ying
Zhu, Mengou
Zhai, Changwen
Qian, Jing
Gao, Xue
Wang, Shuyang
Hou, Yingyong
Lu, Shaohua
Zhu, Hongguang
author_sort Kong, Hui
collection PubMed
description Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with liver metastases and 57 stage I/II CRC specimens. The expression levels of four lncRNAs (GAS5, H19, MEG3 and Yiya) were significantly different between liver metastases and primary tumors of stage IV CRC patients. Furthermore, the high expression levels of GAS5 and Yiya were significantly associated with future occurrence of liver metastases in early stage CRC patients. Kaplan-Meier analysis showed that the high expression levels of GAS5 or Yiya were correlated with poor prognosis of early stage CRC patients (p = 0.0206 and 0.0005 for GAS5 and Yiya, respectively). Yiya expression was proved to be an independent prognostic indicator of colorectal liver metastases in a multivariate analysis (relative risk = 10.7; p < 0.0001). Our study revealed that GAS5 and Yiya were promising prognostic biomarkers of liver metastases for early stage CRC patients.
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spelling pubmed-52265932017-01-18 Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer Kong, Hui Wu, Ying Zhu, Mengou Zhai, Changwen Qian, Jing Gao, Xue Wang, Shuyang Hou, Yingyong Lu, Shaohua Zhu, Hongguang Oncotarget Research Paper Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with liver metastases and 57 stage I/II CRC specimens. The expression levels of four lncRNAs (GAS5, H19, MEG3 and Yiya) were significantly different between liver metastases and primary tumors of stage IV CRC patients. Furthermore, the high expression levels of GAS5 and Yiya were significantly associated with future occurrence of liver metastases in early stage CRC patients. Kaplan-Meier analysis showed that the high expression levels of GAS5 or Yiya were correlated with poor prognosis of early stage CRC patients (p = 0.0206 and 0.0005 for GAS5 and Yiya, respectively). Yiya expression was proved to be an independent prognostic indicator of colorectal liver metastases in a multivariate analysis (relative risk = 10.7; p < 0.0001). Our study revealed that GAS5 and Yiya were promising prognostic biomarkers of liver metastases for early stage CRC patients. Impact Journals LLC 2016-07-06 /pmc/articles/PMC5226593/ /pubmed/27391432 http://dx.doi.org/10.18632/oncotarget.10416 Text en Copyright: © 2016 Kong et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Kong, Hui
Wu, Ying
Zhu, Mengou
Zhai, Changwen
Qian, Jing
Gao, Xue
Wang, Shuyang
Hou, Yingyong
Lu, Shaohua
Zhu, Hongguang
Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer
title Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer
title_full Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer
title_fullStr Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer
title_full_unstemmed Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer
title_short Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer
title_sort long non-coding rnas: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226593/
https://www.ncbi.nlm.nih.gov/pubmed/27391432
http://dx.doi.org/10.18632/oncotarget.10416
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