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Long non-coding RNAs in normal and malignant hematopoiesis
Long non-coding RNAs (lncRNAs) are defined as ncRNAs of more than 200 nt in length. They are involved in a large spectrum of biological processes, such as maintenance of genome integrity, genomic imprinting, cell differentiation, and development by means of mechanisms that remain to be fully elucida...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226612/ https://www.ncbi.nlm.nih.gov/pubmed/27177333 http://dx.doi.org/10.18632/oncotarget.9308 |
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author | Nobili, Lucia Lionetti, Marta Neri, Antonino |
author_facet | Nobili, Lucia Lionetti, Marta Neri, Antonino |
author_sort | Nobili, Lucia |
collection | PubMed |
description | Long non-coding RNAs (lncRNAs) are defined as ncRNAs of more than 200 nt in length. They are involved in a large spectrum of biological processes, such as maintenance of genome integrity, genomic imprinting, cell differentiation, and development by means of mechanisms that remain to be fully elucidated. Besides their role in normal cellular physiology, accumulating evidence has linked lncRNA expression and functions to cancer development and progression. In this review, we summarize and discuss what is known about their expression and roles in hematopoiesis with a particular focus on their cell-type specificity, functional interactions, and involvement in the pathobiology of hematological malignancies. |
format | Online Article Text |
id | pubmed-5226612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-52266122017-01-18 Long non-coding RNAs in normal and malignant hematopoiesis Nobili, Lucia Lionetti, Marta Neri, Antonino Oncotarget Review Long non-coding RNAs (lncRNAs) are defined as ncRNAs of more than 200 nt in length. They are involved in a large spectrum of biological processes, such as maintenance of genome integrity, genomic imprinting, cell differentiation, and development by means of mechanisms that remain to be fully elucidated. Besides their role in normal cellular physiology, accumulating evidence has linked lncRNA expression and functions to cancer development and progression. In this review, we summarize and discuss what is known about their expression and roles in hematopoiesis with a particular focus on their cell-type specificity, functional interactions, and involvement in the pathobiology of hematological malignancies. Impact Journals LLC 2016-05-11 /pmc/articles/PMC5226612/ /pubmed/27177333 http://dx.doi.org/10.18632/oncotarget.9308 Text en Copyright: © 2016 Nobili et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Nobili, Lucia Lionetti, Marta Neri, Antonino Long non-coding RNAs in normal and malignant hematopoiesis |
title | Long non-coding RNAs in normal and malignant hematopoiesis |
title_full | Long non-coding RNAs in normal and malignant hematopoiesis |
title_fullStr | Long non-coding RNAs in normal and malignant hematopoiesis |
title_full_unstemmed | Long non-coding RNAs in normal and malignant hematopoiesis |
title_short | Long non-coding RNAs in normal and malignant hematopoiesis |
title_sort | long non-coding rnas in normal and malignant hematopoiesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226612/ https://www.ncbi.nlm.nih.gov/pubmed/27177333 http://dx.doi.org/10.18632/oncotarget.9308 |
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