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Long non-coding RNAs in normal and malignant hematopoiesis

Long non-coding RNAs (lncRNAs) are defined as ncRNAs of more than 200 nt in length. They are involved in a large spectrum of biological processes, such as maintenance of genome integrity, genomic imprinting, cell differentiation, and development by means of mechanisms that remain to be fully elucida...

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Detalles Bibliográficos
Autores principales: Nobili, Lucia, Lionetti, Marta, Neri, Antonino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226612/
https://www.ncbi.nlm.nih.gov/pubmed/27177333
http://dx.doi.org/10.18632/oncotarget.9308
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author Nobili, Lucia
Lionetti, Marta
Neri, Antonino
author_facet Nobili, Lucia
Lionetti, Marta
Neri, Antonino
author_sort Nobili, Lucia
collection PubMed
description Long non-coding RNAs (lncRNAs) are defined as ncRNAs of more than 200 nt in length. They are involved in a large spectrum of biological processes, such as maintenance of genome integrity, genomic imprinting, cell differentiation, and development by means of mechanisms that remain to be fully elucidated. Besides their role in normal cellular physiology, accumulating evidence has linked lncRNA expression and functions to cancer development and progression. In this review, we summarize and discuss what is known about their expression and roles in hematopoiesis with a particular focus on their cell-type specificity, functional interactions, and involvement in the pathobiology of hematological malignancies.
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spelling pubmed-52266122017-01-18 Long non-coding RNAs in normal and malignant hematopoiesis Nobili, Lucia Lionetti, Marta Neri, Antonino Oncotarget Review Long non-coding RNAs (lncRNAs) are defined as ncRNAs of more than 200 nt in length. They are involved in a large spectrum of biological processes, such as maintenance of genome integrity, genomic imprinting, cell differentiation, and development by means of mechanisms that remain to be fully elucidated. Besides their role in normal cellular physiology, accumulating evidence has linked lncRNA expression and functions to cancer development and progression. In this review, we summarize and discuss what is known about their expression and roles in hematopoiesis with a particular focus on their cell-type specificity, functional interactions, and involvement in the pathobiology of hematological malignancies. Impact Journals LLC 2016-05-11 /pmc/articles/PMC5226612/ /pubmed/27177333 http://dx.doi.org/10.18632/oncotarget.9308 Text en Copyright: © 2016 Nobili et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Nobili, Lucia
Lionetti, Marta
Neri, Antonino
Long non-coding RNAs in normal and malignant hematopoiesis
title Long non-coding RNAs in normal and malignant hematopoiesis
title_full Long non-coding RNAs in normal and malignant hematopoiesis
title_fullStr Long non-coding RNAs in normal and malignant hematopoiesis
title_full_unstemmed Long non-coding RNAs in normal and malignant hematopoiesis
title_short Long non-coding RNAs in normal and malignant hematopoiesis
title_sort long non-coding rnas in normal and malignant hematopoiesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226612/
https://www.ncbi.nlm.nih.gov/pubmed/27177333
http://dx.doi.org/10.18632/oncotarget.9308
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