Cargando…

mTOR: An attractive therapeutic target for osteosarcoma?

Osteosarcoma (OS) is a common primary malignant bone tumor with high morbidity and mortality in children and young adults. How to improve poor prognosis of OS due to resistance to chemotherapy remains a challenge. Recently, growing findings show activation of mammalian target of rapamycin (mTOR), is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ding, Liu, Congwei, Liu, Bei, Qing, Tao, Yang, Ruiguo, Wang, Heze, Yu, Bo, Dou, Zhihong, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226621/ https://www.ncbi.nlm.nih.gov/pubmed/27177330 http://dx.doi.org/10.18632/oncotarget.9305

Ejemplares similares

EGFR and mTOR as therapeutic targets in glioblastoma
por: Ronellenfitsch, Michael W., et al.
Publicado: (2019)

Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma
por: Rathore, Richa, et al.
Publicado: (2021)

mTOR: A Potential Therapeutic Target in Osteoarthritis?
por: Pal, Bandna, et al.
Publicado: (2015)

Targeting mTOR as a Therapeutic Approach in Medulloblastoma
por: Aldaregia, Juncal, et al.
Publicado: (2018)

mTOR Signaling and Potential Therapeutic Targeting in Meningioma
por: Pinker, Benjamin, et al.
Publicado: (2022)

Estrogen receptor β induces autophagy of osteosarcoma through the mTOR signaling pathway
por: Yang, Zhengming, et al.
Publicado: (2020)

Targeting ganglioneuromas with mTOR inhibitors
por: Tao, Ting, et al.
Publicado: (2021)

mTOR Signaling Cascade in Psoriatic Disease: Double Kinase mTOR Inhibitor a Novel Therapeutic Target
por: Raychaudhuri, Smriti K, et al.
Publicado: (2014)

Targeting glutaminase and mTOR
por: Tanaka, Kazuhiro, et al.
Publicado: (2015)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

The Role of mTOR Signaling as a Therapeutic Target in Cancer
por: Popova, Nadezhda V., et al.
Publicado: (2021)

mTOR pathway – a potential therapeutic target in stroke
por: Melanis, Konstantinos, et al.
Publicado: (2023)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
por: Tian, Tian, et al.
Publicado: (2019)

Modulation of mTOR and epigenetic pathways as therapeutics in gallbladder cancer
por: Yang, Dong, et al.
Publicado: (2020)

Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors
por: Tao, Ting, et al.
Publicado: (2020)

Targeting mTOR for cancer therapy
por: Hua, Hui, et al.
Publicado: (2019)

Telmisartan Induces Osteosarcoma Cells Growth Inhibition and Apoptosis Via Suppressing mTOR Pathway
por: Wang, Chao, et al.
Publicado: (2018)

Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update
por: Evangelisti, Camilla, et al.
Publicado: (2018)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer
por: Cao, Guo-dong, et al.
Publicado: (2016)

mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target
por: Babicheva, Aleksandra, et al.
Publicado: (2021)

mTOR kinase is a therapeutic target for respiratory syncytial virus and coronaviruses
por: Huynh, HoangDinh, et al.
Publicado: (2021)

The promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis
por: Platé, Manuela, et al.
Publicado: (2020)

Unveiling Novel Avenues in mTOR-Targeted Therapeutics: Advancements in Glioblastoma Treatment
por: Singh, Shilpi, et al.
Publicado: (2023)

Targeting mTOR dependency in pancreatic cancer
por: Morran, Douglas C, et al.
Publicado: (2014)

Targeting mTOR in Pancreatic Ductal Adenocarcinoma
por: Iriana, Sentia, et al.
Publicado: (2016)

Targeting mTOR in Acute Lymphoblastic Leukemia
por: Simioni, Carolina, et al.
Publicado: (2019)

IDO1 involvement in mTOR pathway: a molecular mechanism of resistance to mTOR targeting in medulloblastoma
por: Folgiero, Valentina, et al.
Publicado: (2016)

Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway
por: Yuan, Baoshi, et al.
Publicado: (2023)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

Downregulation of BZW2 inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway
por: Cheng, Dong-Dong, et al.
Publicado: (2017)

Effect of the Notch1-mediated PI3K-Akt-mTOR pathway in human osteosarcoma
por: Zhang, Kexiang, et al.
Publicado: (2021)

Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway
por: Hu, Binwu, et al.
Publicado: (2017)

Mutational Landscape of PI3K-AKT-mTOR Pathway in Breast Cancer: Implications for Targeted Therapeutics
por: Xiao, Weikai, et al.
Publicado: (2021)

Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis
por: Zhang, Fen, et al.
Publicado: (2023)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
por: Villar, Victor H., et al.
Publicado: (2017)

Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor
por: Rodrik-Outmezguine, Vanessa S., et al.
Publicado: (2016)

Therapeutic targets for cancer: Current concepts with PI 3-K, Akt, & mTOR
por: Maiese, Kenneth
Publicado: (2013)

mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases
por: Wang, Yipin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_57pbfq1p4k637l5qkcuvtejbg3