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Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function
Parkinson's disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra. Parkin (which encoded by Park2), an E3 ubiquitin ligase, is the most frequently mutated gene that has casually been linked to autosomal recessive earl...
Autores principales: | Hwang, Chul Ju, Kim, Young Eun, Son, Dong Ju, Park, Mi Hee, Choi, Dong-Young, Park, Pil-Hoon, Hellström, Mats, Han, Sang-Bae, Oh, Ki-Wan, Park, Eun Kyung, Hong, Jin Tae |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226672/ https://www.ncbi.nlm.nih.gov/pubmed/28086194 http://dx.doi.org/10.1016/j.redox.2016.12.008 |
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