Cargando…

A Chemogenomic Screen Reveals Novel Snf1p/AMPK Independent Regulators of Acetyl-CoA Carboxylase

Acetyl-CoA carboxylase (Acc1p) is a key enzyme in fatty acid biosynthesis and is essential for cell viability. To discover new regulators of its activity, we screened a Saccharomyces cerevisiae deletion library for increased sensitivity to soraphen A, a potent Acc1p inhibitor. The hits identified in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bozaquel-Morais, Bruno L., Madeira, Juliana B., Venâncio, Thiago M., Pacheco-Rosa, Thiago, Masuda, Claudio A., Montero-Lomeli, Monica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226726/ https://www.ncbi.nlm.nih.gov/pubmed/28076367 http://dx.doi.org/10.1371/journal.pone.0169682

Ejemplares similares

Acetyl-CoA Carboxylases and Diseases
por: Wang, Yu, et al.
Publicado: (2022)

Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK
por: Gross, Angelina S., et al.
Publicado: (2019)

Hypothalamic Inhibition of Acetyl-CoA Carboxylase Stimulates Hepatic Counter-Regulatory Response Independent of AMPK Activation in Rats
por: Santos, Gustavo A., et al.
Publicado: (2013)

Chemical Genetics of Acetyl-CoA Carboxylases
por: Zu, Xuyu, et al.
Publicado: (2013)

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis
por: Galic, Sandra, et al.
Publicado: (2018)

A New Fluorescence-Based Method Identifies Protein Phosphatases Regulating Lipid Droplet Metabolism
por: Bozaquel-Morais, Bruno L., et al.
Publicado: (2010)

Retraction: Hypothalamic Inhibition of Acetyl-CoA Carboxylase Stimulates Hepatic Counter-Regulatory Response Independent of AMPK Activation in Rats
Publicado: (2023)

The dynamic organization of fungal acetyl-CoA carboxylase
por: Hunkeler, Moritz, et al.
Publicado: (2016)

Dynamics of the Degradation of Acetyl-CoA Carboxylase Herbicides in Vegetables
por: Jursík, Miroslav, et al.
Publicado: (2021)

Targeting acetyl-CoA carboxylase 1 for cancer therapy
por: Yu, Yong, et al.
Publicado: (2023)

Characterization of Acetyl-CoA Carboxylases in the Basal Dinoflagellate Amphidinium carterae
por: Haq, Saddef, et al.
Publicado: (2017)

Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase
por: Larson, Erica C., et al.
Publicado: (2020)

Alternative polyadenylation regulates acetyl-CoA carboxylase function in peanut
por: Peng, Zhenying, et al.
Publicado: (2023)

Reciprocal Regulation of AMPK/SNF1 and Protein Acetylation
por: Vancura, Ales, et al.
Publicado: (2018)

Sequences of acetyl CoA carboxylase promoter for tumour necrosis factor action
por: Park, Keerang, et al.
Publicado: (1993)

Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis
por: Unissa, Ameeruddin Nusrath, et al.
Publicado: (2011)

Acetyl CoA Carboxylase 2 Is Dispensable for CD8(+) T Cell Responses
por: Lee, Jang Eun, et al.
Publicado: (2015)

A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation
por: Wei, Jia, et al.
Publicado: (2016)

A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation
por: Wei, Jia, et al.
Publicado: (2017)

Acetyl-CoA carboxylase inhibitors in non-alcoholic steatohepatitis: Is there a benefit?
por: Neokosmidis, Georgios, et al.
Publicado: (2021)

Biochemical and structural characterization of quizalofop-resistant wheat acetyl-CoA carboxylase
por: Bough, Raven, et al.
Publicado: (2022)

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program
por: Guilherme, Adilson, et al.
Publicado: (2023)

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK
por: Scaglia, Natalia, et al.
Publicado: (2009)

The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma
por: Li, Kun, et al.
Publicado: (2019)

Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalities
por: Fang, Chieh-Ting, et al.
Publicado: (2023)

Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase 1 and De novo Lipogenesis
por: Scott, Kristen E. N., et al.
Publicado: (2012)

Phylogenetic Analysis of Nucleus-Encoded Acetyl-CoA Carboxylases Targeted at the Cytosol and Plastid of Algae
por: Huerlimann, Roger, et al.
Publicado: (2015)

Underlying Resistance Mechanisms in the Cynosurus echinatus Biotype to Acetyl CoA Carboxylase-Inhibiting Herbicides
por: Fernández, Pablo, et al.
Publicado: (2016)

Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer
por: Wei, Jia, et al.
Publicado: (2015)

Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems
por: Ross, Trenton T., et al.
Publicado: (2020)

Inhibition of acetyl-CoA carboxylase by spirotetramat causes growth arrest and lipid depletion in nematodes
por: Gutbrod, Philipp, et al.
Publicado: (2020)

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation()
por: Chow, Jenny D.Y., et al.
Publicado: (2014)

Expression of Yarrowia lipolytica acetyl-CoA carboxylase in Saccharomyces cerevisiae and its effect on in-vivo accumulation of Malonyl-CoA
por: Pereira, Humberto, et al.
Publicado: (2022)

Two Independent Plastid accD Transfers to the Nuclear Genome of Gnetum and Other Insights on Acetyl-CoA Carboxylase Evolution in Gymnosperms
por: Sudianto, Edi, et al.
Publicado: (2019)

Protein Phosphatase Sit4 Affects Lipid Droplet Synthesis and Soraphen A Resistance Independent of Its Role in Regulating Elongator Dependent tRNA Modification
por: Bozaquel-Morais, Bruno Leonardo, et al.
Publicado: (2018)

Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation
por: Octave, Marie, et al.
Publicado: (2021)

Screening Phosphorylation Site Mutations in Yeast Acetyl-CoA Carboxylase Using Malonyl-CoA Sensor to Improve Malonyl-CoA-Derived Product
por: Chen, Xiaoxu, et al.
Publicado: (2018)

Aberrant mitosis in fission yeast mutants defective in fatty acid synthetase and acetyl CoA carboxylase
Publicado: (1996)

Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells
por: Corominas-Faja, Bruna, et al.
Publicado: (2014)

Acetyl-CoA carboxylase inhibitors attenuate WNT and Hedgehog signaling and suppress pancreatic tumor growth
por: Petrova, Elissaveta, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_o3pgivjqf930fa964qvesaqhfl