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Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation

Intermittently administered parathyroid hormone (PTH 1-34) has been shown to promote bone formation in both human and animal studies. The hormone and its analogues stimulate both bone formation and resorption, and as such at low doses are now in clinical use for the treatment of severe osteoporosis....

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Autores principales: Osagie-Clouard, L., Sanghani, A., Coathup, M., Briggs, T., Bostrom, M., Blunn, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227055/
https://www.ncbi.nlm.nih.gov/pubmed/28062525
http://dx.doi.org/10.1302/2046-3758.61.BJR-2016-0085.R1
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author Osagie-Clouard, L.
Sanghani, A.
Coathup, M.
Briggs, T.
Bostrom, M.
Blunn, G.
author_facet Osagie-Clouard, L.
Sanghani, A.
Coathup, M.
Briggs, T.
Bostrom, M.
Blunn, G.
author_sort Osagie-Clouard, L.
collection PubMed
description Intermittently administered parathyroid hormone (PTH 1-34) has been shown to promote bone formation in both human and animal studies. The hormone and its analogues stimulate both bone formation and resorption, and as such at low doses are now in clinical use for the treatment of severe osteoporosis. By varying the duration of exposure, parathyroid hormone can modulate genes leading to increased bone formation within a so-called ‘anabolic window’. The osteogenic mechanisms involved are multiple, affecting the stimulation of osteoprogenitor cells, osteoblasts, osteocytes and the stem cell niche, and ultimately leading to increased osteoblast activation, reduced osteoblast apoptosis, upregulation of Wnt/β-catenin signalling, increased stem cell mobilisation, and mediation of the RANKL/OPG pathway. Ongoing investigation into their effect on bone formation through ‘coupled’ and ‘uncoupled’ mechanisms further underlines the impact of intermittent PTH on both cortical and cancellous bone. Given the principally catabolic actions of continuous PTH, this article reviews the skeletal actions of intermittent PTH 1-34 and the mechanisms underlying its effect. Cite this article: L. Osagie-Clouard, A. Sanghani, M. Coathup, T. Briggs, M. Bostrom, G. Blunn. Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation. Bone Joint Res 2017;6:14–21. DOI: 10.1302/2046-3758.61.BJR-2016-0085.R1.
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spelling pubmed-52270552017-02-01 Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation Osagie-Clouard, L. Sanghani, A. Coathup, M. Briggs, T. Bostrom, M. Blunn, G. Bone Joint Res Instructional Review - Research Intermittently administered parathyroid hormone (PTH 1-34) has been shown to promote bone formation in both human and animal studies. The hormone and its analogues stimulate both bone formation and resorption, and as such at low doses are now in clinical use for the treatment of severe osteoporosis. By varying the duration of exposure, parathyroid hormone can modulate genes leading to increased bone formation within a so-called ‘anabolic window’. The osteogenic mechanisms involved are multiple, affecting the stimulation of osteoprogenitor cells, osteoblasts, osteocytes and the stem cell niche, and ultimately leading to increased osteoblast activation, reduced osteoblast apoptosis, upregulation of Wnt/β-catenin signalling, increased stem cell mobilisation, and mediation of the RANKL/OPG pathway. Ongoing investigation into their effect on bone formation through ‘coupled’ and ‘uncoupled’ mechanisms further underlines the impact of intermittent PTH on both cortical and cancellous bone. Given the principally catabolic actions of continuous PTH, this article reviews the skeletal actions of intermittent PTH 1-34 and the mechanisms underlying its effect. Cite this article: L. Osagie-Clouard, A. Sanghani, M. Coathup, T. Briggs, M. Bostrom, G. Blunn. Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation. Bone Joint Res 2017;6:14–21. DOI: 10.1302/2046-3758.61.BJR-2016-0085.R1. 2017-01-12 /pmc/articles/PMC5227055/ /pubmed/28062525 http://dx.doi.org/10.1302/2046-3758.61.BJR-2016-0085.R1 Text en © 2017 Osagie-Clouard et al. This is an open-access article distributed under the terms of the Creative Commons Attributions licence (CC-BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited.
spellingShingle Instructional Review - Research
Osagie-Clouard, L.
Sanghani, A.
Coathup, M.
Briggs, T.
Bostrom, M.
Blunn, G.
Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation
title Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation
title_full Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation
title_fullStr Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation
title_full_unstemmed Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation
title_short Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation
title_sort parathyroid hormone 1-34 and skeletal anabolic action: the use of parathyroid hormone in bone formation
topic Instructional Review - Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227055/
https://www.ncbi.nlm.nih.gov/pubmed/28062525
http://dx.doi.org/10.1302/2046-3758.61.BJR-2016-0085.R1
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