Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML

Spontaneous remission (SR) of acute myeloid leukemia (AML) is a very rare phenomenon. AML characterized by FLT3 internal tandem duplication (FLT3 ITD) is typically associated with an aggressive clinical course with rapid progression, relapse, and short overall survival in the absence of transplantat...

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Detalles Bibliográficos
Autores principales: Vachhani, Pankit, Mendler, Jason H., Evans, Andrew, Deeb, George, Starostik, Petr, Wallace, Paul K., Wang, Eunice S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227128/
https://www.ncbi.nlm.nih.gov/pubmed/28127477
http://dx.doi.org/10.1155/2016/1259759
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author Vachhani, Pankit
Mendler, Jason H.
Evans, Andrew
Deeb, George
Starostik, Petr
Wallace, Paul K.
Wang, Eunice S.
author_facet Vachhani, Pankit
Mendler, Jason H.
Evans, Andrew
Deeb, George
Starostik, Petr
Wallace, Paul K.
Wang, Eunice S.
author_sort Vachhani, Pankit
collection PubMed
description Spontaneous remission (SR) of acute myeloid leukemia (AML) is a very rare phenomenon. AML characterized by FLT3 internal tandem duplication (FLT3 ITD) is typically associated with an aggressive clinical course with rapid progression, relapse, and short overall survival in the absence of transplantation. We report here the first case of SR of FLT3 ITD mutant AML in the literature. Our patient was an elderly woman with relapsed NPM1 and FLT3 ITD mutant AML whose disease underwent SR for a brief duration without precipitating cause. We review the potential immune mechanisms underlying SR in AML and discuss the implications for novel immunotherapeutic approaches for FLT3 mutant AML.
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spelling pubmed-52271282017-01-26 Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML Vachhani, Pankit Mendler, Jason H. Evans, Andrew Deeb, George Starostik, Petr Wallace, Paul K. Wang, Eunice S. Case Rep Hematol Case Report Spontaneous remission (SR) of acute myeloid leukemia (AML) is a very rare phenomenon. AML characterized by FLT3 internal tandem duplication (FLT3 ITD) is typically associated with an aggressive clinical course with rapid progression, relapse, and short overall survival in the absence of transplantation. We report here the first case of SR of FLT3 ITD mutant AML in the literature. Our patient was an elderly woman with relapsed NPM1 and FLT3 ITD mutant AML whose disease underwent SR for a brief duration without precipitating cause. We review the potential immune mechanisms underlying SR in AML and discuss the implications for novel immunotherapeutic approaches for FLT3 mutant AML. Hindawi Publishing Corporation 2016 2016-12-29 /pmc/articles/PMC5227128/ /pubmed/28127477 http://dx.doi.org/10.1155/2016/1259759 Text en Copyright © 2016 Pankit Vachhani et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Vachhani, Pankit
Mendler, Jason H.
Evans, Andrew
Deeb, George
Starostik, Petr
Wallace, Paul K.
Wang, Eunice S.
Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML
title Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML
title_full Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML
title_fullStr Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML
title_full_unstemmed Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML
title_short Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML
title_sort spontaneous remission in an older patient with relapsed flt3 itd mutant aml
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227128/
https://www.ncbi.nlm.nih.gov/pubmed/28127477
http://dx.doi.org/10.1155/2016/1259759
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