The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study

Introduction. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection. The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. Aim. The present study aimed to investigate the involvement of myeloid differentiation primary resp...

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Autores principales: Aggelou, Kalliopi, Siapati, Elena Konstantina, Gerogianni, Irini, Daniil, Zoe, Gourgoulianis, Konstantinos, Ntanos, Ioannis, Simantirakis, Emmanouel, Zintzaras, Elias, Mollaki, Vassiliki, Vassilopoulos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
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Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227150/
https://www.ncbi.nlm.nih.gov/pubmed/28127112
http://dx.doi.org/10.1155/2016/4961086
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author Aggelou, Kalliopi
Siapati, Elena Konstantina
Gerogianni, Irini
Daniil, Zoe
Gourgoulianis, Konstantinos
Ntanos, Ioannis
Simantirakis, Emmanouel
Zintzaras, Elias
Mollaki, Vassiliki
Vassilopoulos, George
author_facet Aggelou, Kalliopi
Siapati, Elena Konstantina
Gerogianni, Irini
Daniil, Zoe
Gourgoulianis, Konstantinos
Ntanos, Ioannis
Simantirakis, Emmanouel
Zintzaras, Elias
Mollaki, Vassiliki
Vassilopoulos, George
author_sort Aggelou, Kalliopi
collection PubMed
description Introduction. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection. The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. Aim. The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms in TB. Materials and Methods. A total of 103 TB cases and 92 control subjects were genotyped for the MYD88 -938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms. Results. The MYD88 -938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89–11.28, p = 0.01). Conclusions. The MYD88 -938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk.
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spelling pubmed-52271502017-01-26 The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study Aggelou, Kalliopi Siapati, Elena Konstantina Gerogianni, Irini Daniil, Zoe Gourgoulianis, Konstantinos Ntanos, Ioannis Simantirakis, Emmanouel Zintzaras, Elias Mollaki, Vassiliki Vassilopoulos, George Dis Markers Research Article Introduction. Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection. The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB. Aim. The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms in TB. Materials and Methods. A total of 103 TB cases and 92 control subjects were genotyped for the MYD88 -938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms. Results. The MYD88 -938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89–11.28, p = 0.01). Conclusions. The MYD88 -938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk. Hindawi Publishing Corporation 2016 2016-12-29 /pmc/articles/PMC5227150/ /pubmed/28127112 http://dx.doi.org/10.1155/2016/4961086 Text en Copyright © 2016 Kalliopi Aggelou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aggelou, Kalliopi
Siapati, Elena Konstantina
Gerogianni, Irini
Daniil, Zoe
Gourgoulianis, Konstantinos
Ntanos, Ioannis
Simantirakis, Emmanouel
Zintzaras, Elias
Mollaki, Vassiliki
Vassilopoulos, George
The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study
title The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study
title_full The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study
title_fullStr The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study
title_full_unstemmed The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study
title_short The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study
title_sort -938c>a polymorphism in myd88 is associated with susceptibility to tuberculosis: a pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227150/
https://www.ncbi.nlm.nih.gov/pubmed/28127112
http://dx.doi.org/10.1155/2016/4961086
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