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Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis
There is currently no effective treatment for acute exacerbation of idiopathic pulmonary fibrosis (IPF). We herein report the case of a patient with acute exacerbation of IPF which was treated with nintedanib, an intracellular inhibitor of tyrosine kinases, and showed improvement of the condition. A...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227291/ https://www.ncbi.nlm.nih.gov/pubmed/28096998 http://dx.doi.org/10.1002/rcr2.215 |
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author | Tomioka, Hiromi Takada, Hirohito |
author_facet | Tomioka, Hiromi Takada, Hirohito |
author_sort | Tomioka, Hiromi |
collection | PubMed |
description | There is currently no effective treatment for acute exacerbation of idiopathic pulmonary fibrosis (IPF). We herein report the case of a patient with acute exacerbation of IPF which was treated with nintedanib, an intracellular inhibitor of tyrosine kinases, and showed improvement of the condition. An 84‐year‐old man with IPF was admitted to our hospital because of dry cough and worsening of dyspnoea within last 1 month. He presented with hypoxemia, and chest high‐resolution computed tomography (HRCT) revealed new, bilateral multifocal ground‐glass opacities superimposed on the background of lung fibrosis. After exclusion of alternative causes, acute exacerbation of IPF was diagnosed and we started treatment with nintedanib of 300 mg/day. This resulted in the gradual improvement of his condition and HRCT findings without administering antibiotics or corticosteroids. Serum Krebs von den Lungen‐6 and surfactant protein D levels increased at acute exacerbation and subsequently decreased. This case suggests that nintedanib therapy may have possible benefits in acute exacerbation of IPF. |
format | Online Article Text |
id | pubmed-5227291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-52272912017-01-17 Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis Tomioka, Hiromi Takada, Hirohito Respirol Case Rep Case Reports There is currently no effective treatment for acute exacerbation of idiopathic pulmonary fibrosis (IPF). We herein report the case of a patient with acute exacerbation of IPF which was treated with nintedanib, an intracellular inhibitor of tyrosine kinases, and showed improvement of the condition. An 84‐year‐old man with IPF was admitted to our hospital because of dry cough and worsening of dyspnoea within last 1 month. He presented with hypoxemia, and chest high‐resolution computed tomography (HRCT) revealed new, bilateral multifocal ground‐glass opacities superimposed on the background of lung fibrosis. After exclusion of alternative causes, acute exacerbation of IPF was diagnosed and we started treatment with nintedanib of 300 mg/day. This resulted in the gradual improvement of his condition and HRCT findings without administering antibiotics or corticosteroids. Serum Krebs von den Lungen‐6 and surfactant protein D levels increased at acute exacerbation and subsequently decreased. This case suggests that nintedanib therapy may have possible benefits in acute exacerbation of IPF. John Wiley & Sons, Ltd 2017-01-12 /pmc/articles/PMC5227291/ /pubmed/28096998 http://dx.doi.org/10.1002/rcr2.215 Text en © 2017 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Tomioka, Hiromi Takada, Hirohito Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis |
title | Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis |
title_full | Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis |
title_fullStr | Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis |
title_full_unstemmed | Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis |
title_short | Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis |
title_sort | treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227291/ https://www.ncbi.nlm.nih.gov/pubmed/28096998 http://dx.doi.org/10.1002/rcr2.215 |
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