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Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage

A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The assoc...

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Autores principales: Malm, Gunilla, Haugen, Trine B, Rylander, Lars, Giwercman, Aleksander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227675/
https://www.ncbi.nlm.nih.gov/pubmed/27748316
http://dx.doi.org/10.4103/1008-682X.186870
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author Malm, Gunilla
Haugen, Trine B
Rylander, Lars
Giwercman, Aleksander
author_facet Malm, Gunilla
Haugen, Trine B
Rylander, Lars
Giwercman, Aleksander
author_sort Malm, Gunilla
collection PubMed
description A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The association between the major melatonin metabolite, urine 6-sulfatoxymelatonin (aMT6s), and DFI was analyzed in 110 Oslo men (south of the Arctic Circle) and 86 Tromsoe men (north of the Arctic Circle). Two semen analyses, summer and winter, and four urine samples (early/late summer; early/late winter), were analyzed. The associations between aMT6s in urine and DFI were characterized in a cross-sectional and longitudinal manner using correlation analysis and linear regression. Regardless of season and location, no significant correlations between aMT6s and DFI were observed. The correlation coefficients for associations between changes over time (early winter–early summer) in aMT6s and DFI were for the total cohort: rho = −0.08 (P = 0.322), for the Oslo cohort: rho = −0.07 (P = 0.485), and for the Tromsoe cohort: rho = −0.14 (P = 0.273), respectively. Similar results were seen when comparing late winter and late summer. There was no any statistically significant correlation between changes over time in aMT6s and DFI for men with DFI below and above the median value (10%), respectively. The seasonal variation in melatonin excretion seems not to have any impact on DFI.
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spelling pubmed-52276752017-02-03 Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage Malm, Gunilla Haugen, Trine B Rylander, Lars Giwercman, Aleksander Asian J Androl Original Article A high sperm DNA fragmentation index (DFI) is associated with reduced fertility. DFI is influenced by the balance between reactive oxygen species and antioxidants. A circannual variation in melatonin, an antioxidant and free radical scavenger, could thus impact semen quality and fertility. The association between the major melatonin metabolite, urine 6-sulfatoxymelatonin (aMT6s), and DFI was analyzed in 110 Oslo men (south of the Arctic Circle) and 86 Tromsoe men (north of the Arctic Circle). Two semen analyses, summer and winter, and four urine samples (early/late summer; early/late winter), were analyzed. The associations between aMT6s in urine and DFI were characterized in a cross-sectional and longitudinal manner using correlation analysis and linear regression. Regardless of season and location, no significant correlations between aMT6s and DFI were observed. The correlation coefficients for associations between changes over time (early winter–early summer) in aMT6s and DFI were for the total cohort: rho = −0.08 (P = 0.322), for the Oslo cohort: rho = −0.07 (P = 0.485), and for the Tromsoe cohort: rho = −0.14 (P = 0.273), respectively. Similar results were seen when comparing late winter and late summer. There was no any statistically significant correlation between changes over time in aMT6s and DFI for men with DFI below and above the median value (10%), respectively. The seasonal variation in melatonin excretion seems not to have any impact on DFI. Medknow Publications & Media Pvt Ltd 2017 2016-10-14 /pmc/articles/PMC5227675/ /pubmed/27748316 http://dx.doi.org/10.4103/1008-682X.186870 Text en Copyright: © 2017 AJA, SIMM & SJTU http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Malm, Gunilla
Haugen, Trine B
Rylander, Lars
Giwercman, Aleksander
Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage
title Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage
title_full Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage
title_fullStr Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage
title_full_unstemmed Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage
title_short Seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm DNA damage
title_sort seasonal fluctuation in the secretion of the antioxidant melatonin is not associated with alterations in sperm dna damage
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227675/
https://www.ncbi.nlm.nih.gov/pubmed/27748316
http://dx.doi.org/10.4103/1008-682X.186870
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