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SOCS1 favors the epithelial-mesenchymal transition in melanoma, promotes tumor progression and prevents antitumor immunity by PD-L1 expression

Silencing of SOCS1 protein with shRNAi lentivirus (shR-SOCS1) led to partial reversion of the tumorigenic phenotype of B16F10-Nex2 melanoma cells. SOCS1 silencing inhibited cell migration and invasion as well as in vitro growth by cell cycle arrest at S phase with increased cell size and nuclei. Dow...

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Detalles Bibliográficos
Autores principales:	Berzaghi, R., Maia, V. S. C., Pereira, F. V., Melo, F. M., Guedes, M. S., Origassa, C. S. T., Scutti, J. B., Matsuo, A. L., Câmara, N. O. S., Rodrigues, E. G., Travassos, L. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227698/ https://www.ncbi.nlm.nih.gov/pubmed/28079159 http://dx.doi.org/10.1038/srep40585

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