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Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice

Tetrahydrobiopterin (BH4) is a cofactor of a number of regulatory enzymes. Although there are no known BH4 exogenous sources, the tissue content of this biopterin increases with age in GTP cyclohydrolase 1-deficient hyperphenylalaninemia-1 (hph-1) mice. Since certain bacteria are known to generate B...

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Detalles Bibliográficos
Autores principales:	Belik, Jaques, Shifrin, Yulia, Arning, Erland, Bottiglieri, Teodoro, Pan, Jingyi, Daigneault, Michelle C., Allen-Vercoe, Emma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227711/ https://www.ncbi.nlm.nih.gov/pubmed/28079055 http://dx.doi.org/10.1038/srep39854

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