The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

Mutations of DOCK8 in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. However, the molecular link between DOCK8 deficiency and atopic skin inflammation is unknown. Here we show that CD4(+) T cells from DOCK8-deficient mice produce large amounts...

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Detalles Bibliográficos
Autores principales: Yamamura, Kazuhiko, Uruno, Takehito, Shiraishi, Akira, Tanaka, Yoshihiko, Ushijima, Miho, Nakahara, Takeshi, Watanabe, Mayuki, Kido-Nakahara, Makiko, Tsuge, Ikuya, Furue, Masutaka, Fukui, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228069/
https://www.ncbi.nlm.nih.gov/pubmed/28067314
http://dx.doi.org/10.1038/ncomms13946

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