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Extramedullary hematopoiesis: A report of two cases
Extramedullary hematopoiesis (EMH) is defined as hematopoiesis occurring in organs outside of the bone marrow. The present report describes two cases of thalassemic patients with paraspinal medullary hematopoiesis and analyzes the clinical manifestations, imaging, pathology, diagnosis and treatment...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228087/ https://www.ncbi.nlm.nih.gov/pubmed/28101170 http://dx.doi.org/10.3892/etm.2016.3855 |
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author | Zhang, Huan-Zhu Li, Ying Liu, Xin Chen, Bao-Rong Yao, Guo-Hua Peng, Yu-Na |
author_facet | Zhang, Huan-Zhu Li, Ying Liu, Xin Chen, Bao-Rong Yao, Guo-Hua Peng, Yu-Na |
author_sort | Zhang, Huan-Zhu |
collection | PubMed |
description | Extramedullary hematopoiesis (EMH) is defined as hematopoiesis occurring in organs outside of the bone marrow. The present report describes two cases of thalassemic patients with paraspinal medullary hematopoiesis and analyzes the clinical manifestations, imaging, pathology, diagnosis and treatment of EMH. In addition, a supplementary review of previously published cases is provided along with a review of the related literature. Computed tomography (CT) of the first case revealed multiple paraspinal masses, and the largest was 6.2×8.0 cm in diameter. Likewise, CT of the second patient revealed multiple paraspinal masses in the bottom of the left thoracic cavity, and the largest was measured 10.1×10.5 cm. The two cases underwent surgical biopsy and the findings were compatible with a diagnosis of EMH. In conclusion, EMH is a compatible and rare disease, and should be distinguished from other neoplasms. EMH must considered when masses with characteristic radiologic appearance are detected in patients with thalassemia intermedia. |
format | Online Article Text |
id | pubmed-5228087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-52280872017-01-18 Extramedullary hematopoiesis: A report of two cases Zhang, Huan-Zhu Li, Ying Liu, Xin Chen, Bao-Rong Yao, Guo-Hua Peng, Yu-Na Exp Ther Med Articles Extramedullary hematopoiesis (EMH) is defined as hematopoiesis occurring in organs outside of the bone marrow. The present report describes two cases of thalassemic patients with paraspinal medullary hematopoiesis and analyzes the clinical manifestations, imaging, pathology, diagnosis and treatment of EMH. In addition, a supplementary review of previously published cases is provided along with a review of the related literature. Computed tomography (CT) of the first case revealed multiple paraspinal masses, and the largest was 6.2×8.0 cm in diameter. Likewise, CT of the second patient revealed multiple paraspinal masses in the bottom of the left thoracic cavity, and the largest was measured 10.1×10.5 cm. The two cases underwent surgical biopsy and the findings were compatible with a diagnosis of EMH. In conclusion, EMH is a compatible and rare disease, and should be distinguished from other neoplasms. EMH must considered when masses with characteristic radiologic appearance are detected in patients with thalassemia intermedia. D.A. Spandidos 2016-12 2016-11-02 /pmc/articles/PMC5228087/ /pubmed/28101170 http://dx.doi.org/10.3892/etm.2016.3855 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Zhang, Huan-Zhu Li, Ying Liu, Xin Chen, Bao-Rong Yao, Guo-Hua Peng, Yu-Na Extramedullary hematopoiesis: A report of two cases |
title | Extramedullary hematopoiesis: A report of two cases |
title_full | Extramedullary hematopoiesis: A report of two cases |
title_fullStr | Extramedullary hematopoiesis: A report of two cases |
title_full_unstemmed | Extramedullary hematopoiesis: A report of two cases |
title_short | Extramedullary hematopoiesis: A report of two cases |
title_sort | extramedullary hematopoiesis: a report of two cases |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228087/ https://www.ncbi.nlm.nih.gov/pubmed/28101170 http://dx.doi.org/10.3892/etm.2016.3855 |
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