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Extramedullary hematopoiesis: A report of two cases

Extramedullary hematopoiesis (EMH) is defined as hematopoiesis occurring in organs outside of the bone marrow. The present report describes two cases of thalassemic patients with paraspinal medullary hematopoiesis and analyzes the clinical manifestations, imaging, pathology, diagnosis and treatment...

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Autores principales: Zhang, Huan-Zhu, Li, Ying, Liu, Xin, Chen, Bao-Rong, Yao, Guo-Hua, Peng, Yu-Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228087/
https://www.ncbi.nlm.nih.gov/pubmed/28101170
http://dx.doi.org/10.3892/etm.2016.3855
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author Zhang, Huan-Zhu
Li, Ying
Liu, Xin
Chen, Bao-Rong
Yao, Guo-Hua
Peng, Yu-Na
author_facet Zhang, Huan-Zhu
Li, Ying
Liu, Xin
Chen, Bao-Rong
Yao, Guo-Hua
Peng, Yu-Na
author_sort Zhang, Huan-Zhu
collection PubMed
description Extramedullary hematopoiesis (EMH) is defined as hematopoiesis occurring in organs outside of the bone marrow. The present report describes two cases of thalassemic patients with paraspinal medullary hematopoiesis and analyzes the clinical manifestations, imaging, pathology, diagnosis and treatment of EMH. In addition, a supplementary review of previously published cases is provided along with a review of the related literature. Computed tomography (CT) of the first case revealed multiple paraspinal masses, and the largest was 6.2×8.0 cm in diameter. Likewise, CT of the second patient revealed multiple paraspinal masses in the bottom of the left thoracic cavity, and the largest was measured 10.1×10.5 cm. The two cases underwent surgical biopsy and the findings were compatible with a diagnosis of EMH. In conclusion, EMH is a compatible and rare disease, and should be distinguished from other neoplasms. EMH must considered when masses with characteristic radiologic appearance are detected in patients with thalassemia intermedia.
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spelling pubmed-52280872017-01-18 Extramedullary hematopoiesis: A report of two cases Zhang, Huan-Zhu Li, Ying Liu, Xin Chen, Bao-Rong Yao, Guo-Hua Peng, Yu-Na Exp Ther Med Articles Extramedullary hematopoiesis (EMH) is defined as hematopoiesis occurring in organs outside of the bone marrow. The present report describes two cases of thalassemic patients with paraspinal medullary hematopoiesis and analyzes the clinical manifestations, imaging, pathology, diagnosis and treatment of EMH. In addition, a supplementary review of previously published cases is provided along with a review of the related literature. Computed tomography (CT) of the first case revealed multiple paraspinal masses, and the largest was 6.2×8.0 cm in diameter. Likewise, CT of the second patient revealed multiple paraspinal masses in the bottom of the left thoracic cavity, and the largest was measured 10.1×10.5 cm. The two cases underwent surgical biopsy and the findings were compatible with a diagnosis of EMH. In conclusion, EMH is a compatible and rare disease, and should be distinguished from other neoplasms. EMH must considered when masses with characteristic radiologic appearance are detected in patients with thalassemia intermedia. D.A. Spandidos 2016-12 2016-11-02 /pmc/articles/PMC5228087/ /pubmed/28101170 http://dx.doi.org/10.3892/etm.2016.3855 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhang, Huan-Zhu
Li, Ying
Liu, Xin
Chen, Bao-Rong
Yao, Guo-Hua
Peng, Yu-Na
Extramedullary hematopoiesis: A report of two cases
title Extramedullary hematopoiesis: A report of two cases
title_full Extramedullary hematopoiesis: A report of two cases
title_fullStr Extramedullary hematopoiesis: A report of two cases
title_full_unstemmed Extramedullary hematopoiesis: A report of two cases
title_short Extramedullary hematopoiesis: A report of two cases
title_sort extramedullary hematopoiesis: a report of two cases
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228087/
https://www.ncbi.nlm.nih.gov/pubmed/28101170
http://dx.doi.org/10.3892/etm.2016.3855
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