IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules

IGF-IR is highly associated with the behaviour of breast cancer cells. In ERα-positive breast cancer, IGF-IR is present at high levels. In clinical practice, prolonged treatment with anti-estrogen agents results in resistance to the therapy with activation of alternative signaling pathways. Receptor...

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Detalles Bibliográficos
Autores principales: Afratis, Nikolaos A., Bouris, Panagiotis, Skandalis, Spyros S., Multhaupt, Hinke A., Couchman, John R., Theocharis, Achilleas D., Karamanos, Nikos K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228153/
https://www.ncbi.nlm.nih.gov/pubmed/28079144
http://dx.doi.org/10.1038/srep40138

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