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Elevated expression of Nrf2 mediates multidrug resistance in CD133(+) head and neck squamous cell carcinoma stem cells

Enhanced expression of the ATP-binding cassette (ABC) transporter protein ABC sub-family G member 2 (ABCG2) in cancer stem cells (CSCs) plays a major role in chemotherapeutic drug efflux, which results in therapy failure and tumor relapse. In addition to downregulating apoptosis in CSCs, it has been...

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Detalles Bibliográficos
Autores principales:	Lu, Bao-Cai, Li, Jing, Yu, Wen-Fa, Zhang, Guo-Zheng, Wang, Hui-Min, Ma, Hui-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228276/ https://www.ncbi.nlm.nih.gov/pubmed/28101198 http://dx.doi.org/10.3892/ol.2016.5269

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