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Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs
INTRODUCTION: The role played by several vasoactive mediators that are synthesized and released by the pulmonary vascular endothelium in the regulation of hypoxic pulmonary vasoconstriction (HPV) remains unclear. As a potent vasoconstrictor, angiotensin II could be involved. We tested the hypothesis...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC522832/ https://www.ncbi.nlm.nih.gov/pubmed/15312214 http://dx.doi.org/10.1186/cc2860 |
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author | Hubloue, Ives Rondelet, Benoît Kerbaul, François Biarent, Dominique Milani, Guiti Malekzadeh Staroukine, Michel Bergmann, Pierre Naeije, Robert Leeman, Marc |
author_facet | Hubloue, Ives Rondelet, Benoît Kerbaul, François Biarent, Dominique Milani, Guiti Malekzadeh Staroukine, Michel Bergmann, Pierre Naeije, Robert Leeman, Marc |
author_sort | Hubloue, Ives |
collection | PubMed |
description | INTRODUCTION: The role played by several vasoactive mediators that are synthesized and released by the pulmonary vascular endothelium in the regulation of hypoxic pulmonary vasoconstriction (HPV) remains unclear. As a potent vasoconstrictor, angiotensin II could be involved. We tested the hypothesis that angiotensin-converting enzyme inhibition by enalaprilat and type 1 angiotensin II receptor blockade by candesartan would inhibit HPV. METHODS: HPV was evaluated in anaesthetized dogs, with an intact pulmonary circulation, by examining the increase in the Ppa–Ppao gradient (mean pulmonary artery pressure minus occluded pulmonary artery pressure) that occurred in response to hypoxia (inspiratory oxygen fraction of 0.1) at constant pulmonary blood flow. Plasma renin activity and angiotensin II immunoreactivity were measured to determine whether activation or inhibition of the renin–angiotensin system was present. RESULTS: Administration of enalaprilat and candesartan did not affect the Ppa–Ppao gradient at baseline or during hypoxia. Plasma renin activity and angiotensin II immunoreactivity increased during hypoxia, and subsequent measurements were consistent with effective angiotensin-converting enzyme inhibition after administration of enalaprilat, and with angiotensin receptor blockade after administration of candesartan. CONCLUSION: These results suggest that, although the renin–angiotensin system was activated in hypoxia, angiotensin II is not normally involved in mediating acute HPV. |
format | Text |
id | pubmed-522832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-5228322004-10-17 Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs Hubloue, Ives Rondelet, Benoît Kerbaul, François Biarent, Dominique Milani, Guiti Malekzadeh Staroukine, Michel Bergmann, Pierre Naeije, Robert Leeman, Marc Crit Care Research INTRODUCTION: The role played by several vasoactive mediators that are synthesized and released by the pulmonary vascular endothelium in the regulation of hypoxic pulmonary vasoconstriction (HPV) remains unclear. As a potent vasoconstrictor, angiotensin II could be involved. We tested the hypothesis that angiotensin-converting enzyme inhibition by enalaprilat and type 1 angiotensin II receptor blockade by candesartan would inhibit HPV. METHODS: HPV was evaluated in anaesthetized dogs, with an intact pulmonary circulation, by examining the increase in the Ppa–Ppao gradient (mean pulmonary artery pressure minus occluded pulmonary artery pressure) that occurred in response to hypoxia (inspiratory oxygen fraction of 0.1) at constant pulmonary blood flow. Plasma renin activity and angiotensin II immunoreactivity were measured to determine whether activation or inhibition of the renin–angiotensin system was present. RESULTS: Administration of enalaprilat and candesartan did not affect the Ppa–Ppao gradient at baseline or during hypoxia. Plasma renin activity and angiotensin II immunoreactivity increased during hypoxia, and subsequent measurements were consistent with effective angiotensin-converting enzyme inhibition after administration of enalaprilat, and with angiotensin receptor blockade after administration of candesartan. CONCLUSION: These results suggest that, although the renin–angiotensin system was activated in hypoxia, angiotensin II is not normally involved in mediating acute HPV. BioMed Central 2004 2004-05-14 /pmc/articles/PMC522832/ /pubmed/15312214 http://dx.doi.org/10.1186/cc2860 Text en Copyright © 2004 Hubloue et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Research Hubloue, Ives Rondelet, Benoît Kerbaul, François Biarent, Dominique Milani, Guiti Malekzadeh Staroukine, Michel Bergmann, Pierre Naeije, Robert Leeman, Marc Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs |
title | Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs |
title_full | Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs |
title_fullStr | Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs |
title_full_unstemmed | Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs |
title_short | Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs |
title_sort | endogenous angiotensin ii in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC522832/ https://www.ncbi.nlm.nih.gov/pubmed/15312214 http://dx.doi.org/10.1186/cc2860 |
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