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Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer

Pegfilgrastim is a long-acting granulocyte colony-stimulating factor formulation that has been approved for the prevention of febrile neutropenia. We herein report a case of interstitial pneumonia following administration of pegfilgrastim. A 65-year-old man with stage IV small-cell lung cancer was t...

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Autores principales: Shirasawa, Masayuki, Nakahara, Yoshiro, Niwa, Hideyuki, Harada, Shinya, Ozawa, Takahiro, Kusuhara, Seiichiro, Kasajima, Masashi, Hiyoshi, Yasuhiro, Sasaki, Jiichiro, Masuda, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228332/
https://www.ncbi.nlm.nih.gov/pubmed/28105350
http://dx.doi.org/10.3892/mco.2016.1062
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author Shirasawa, Masayuki
Nakahara, Yoshiro
Niwa, Hideyuki
Harada, Shinya
Ozawa, Takahiro
Kusuhara, Seiichiro
Kasajima, Masashi
Hiyoshi, Yasuhiro
Sasaki, Jiichiro
Masuda, Noriyuki
author_facet Shirasawa, Masayuki
Nakahara, Yoshiro
Niwa, Hideyuki
Harada, Shinya
Ozawa, Takahiro
Kusuhara, Seiichiro
Kasajima, Masashi
Hiyoshi, Yasuhiro
Sasaki, Jiichiro
Masuda, Noriyuki
author_sort Shirasawa, Masayuki
collection PubMed
description Pegfilgrastim is a long-acting granulocyte colony-stimulating factor formulation that has been approved for the prevention of febrile neutropenia. We herein report a case of interstitial pneumonia following administration of pegfilgrastim. A 65-year-old man with stage IV small-cell lung cancer was treated with carboplatin and etoposide as third-line chemotherapy. Pegfilgrastim was administered during the second cycle of chemotherapy. On the day after the administration of pegfilgrastim, interstitial pneumonia developed. The respiratory condition improved with pulse steroid therapy; however, the patient eventually succumbed to cancer progression. In conclusion, interstitial pneumonia due to pegfilgrastim is rare; however, physicians should be aware of the possibility of this adverse effect.
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spelling pubmed-52283322017-01-19 Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer Shirasawa, Masayuki Nakahara, Yoshiro Niwa, Hideyuki Harada, Shinya Ozawa, Takahiro Kusuhara, Seiichiro Kasajima, Masashi Hiyoshi, Yasuhiro Sasaki, Jiichiro Masuda, Noriyuki Mol Clin Oncol Articles Pegfilgrastim is a long-acting granulocyte colony-stimulating factor formulation that has been approved for the prevention of febrile neutropenia. We herein report a case of interstitial pneumonia following administration of pegfilgrastim. A 65-year-old man with stage IV small-cell lung cancer was treated with carboplatin and etoposide as third-line chemotherapy. Pegfilgrastim was administered during the second cycle of chemotherapy. On the day after the administration of pegfilgrastim, interstitial pneumonia developed. The respiratory condition improved with pulse steroid therapy; however, the patient eventually succumbed to cancer progression. In conclusion, interstitial pneumonia due to pegfilgrastim is rare; however, physicians should be aware of the possibility of this adverse effect. D.A. Spandidos 2016-12 2016-10-26 /pmc/articles/PMC5228332/ /pubmed/28105350 http://dx.doi.org/10.3892/mco.2016.1062 Text en Copyright: © Shirasawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Shirasawa, Masayuki
Nakahara, Yoshiro
Niwa, Hideyuki
Harada, Shinya
Ozawa, Takahiro
Kusuhara, Seiichiro
Kasajima, Masashi
Hiyoshi, Yasuhiro
Sasaki, Jiichiro
Masuda, Noriyuki
Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer
title Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer
title_full Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer
title_fullStr Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer
title_full_unstemmed Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer
title_short Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer
title_sort interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228332/
https://www.ncbi.nlm.nih.gov/pubmed/28105350
http://dx.doi.org/10.3892/mco.2016.1062
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