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Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer
Pegfilgrastim is a long-acting granulocyte colony-stimulating factor formulation that has been approved for the prevention of febrile neutropenia. We herein report a case of interstitial pneumonia following administration of pegfilgrastim. A 65-year-old man with stage IV small-cell lung cancer was t...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228332/ https://www.ncbi.nlm.nih.gov/pubmed/28105350 http://dx.doi.org/10.3892/mco.2016.1062 |
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author | Shirasawa, Masayuki Nakahara, Yoshiro Niwa, Hideyuki Harada, Shinya Ozawa, Takahiro Kusuhara, Seiichiro Kasajima, Masashi Hiyoshi, Yasuhiro Sasaki, Jiichiro Masuda, Noriyuki |
author_facet | Shirasawa, Masayuki Nakahara, Yoshiro Niwa, Hideyuki Harada, Shinya Ozawa, Takahiro Kusuhara, Seiichiro Kasajima, Masashi Hiyoshi, Yasuhiro Sasaki, Jiichiro Masuda, Noriyuki |
author_sort | Shirasawa, Masayuki |
collection | PubMed |
description | Pegfilgrastim is a long-acting granulocyte colony-stimulating factor formulation that has been approved for the prevention of febrile neutropenia. We herein report a case of interstitial pneumonia following administration of pegfilgrastim. A 65-year-old man with stage IV small-cell lung cancer was treated with carboplatin and etoposide as third-line chemotherapy. Pegfilgrastim was administered during the second cycle of chemotherapy. On the day after the administration of pegfilgrastim, interstitial pneumonia developed. The respiratory condition improved with pulse steroid therapy; however, the patient eventually succumbed to cancer progression. In conclusion, interstitial pneumonia due to pegfilgrastim is rare; however, physicians should be aware of the possibility of this adverse effect. |
format | Online Article Text |
id | pubmed-5228332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-52283322017-01-19 Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer Shirasawa, Masayuki Nakahara, Yoshiro Niwa, Hideyuki Harada, Shinya Ozawa, Takahiro Kusuhara, Seiichiro Kasajima, Masashi Hiyoshi, Yasuhiro Sasaki, Jiichiro Masuda, Noriyuki Mol Clin Oncol Articles Pegfilgrastim is a long-acting granulocyte colony-stimulating factor formulation that has been approved for the prevention of febrile neutropenia. We herein report a case of interstitial pneumonia following administration of pegfilgrastim. A 65-year-old man with stage IV small-cell lung cancer was treated with carboplatin and etoposide as third-line chemotherapy. Pegfilgrastim was administered during the second cycle of chemotherapy. On the day after the administration of pegfilgrastim, interstitial pneumonia developed. The respiratory condition improved with pulse steroid therapy; however, the patient eventually succumbed to cancer progression. In conclusion, interstitial pneumonia due to pegfilgrastim is rare; however, physicians should be aware of the possibility of this adverse effect. D.A. Spandidos 2016-12 2016-10-26 /pmc/articles/PMC5228332/ /pubmed/28105350 http://dx.doi.org/10.3892/mco.2016.1062 Text en Copyright: © Shirasawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Shirasawa, Masayuki Nakahara, Yoshiro Niwa, Hideyuki Harada, Shinya Ozawa, Takahiro Kusuhara, Seiichiro Kasajima, Masashi Hiyoshi, Yasuhiro Sasaki, Jiichiro Masuda, Noriyuki Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer |
title | Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer |
title_full | Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer |
title_fullStr | Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer |
title_full_unstemmed | Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer |
title_short | Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer |
title_sort | interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small-cell lung cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228332/ https://www.ncbi.nlm.nih.gov/pubmed/28105350 http://dx.doi.org/10.3892/mco.2016.1062 |
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