Cargando…

Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment

High global incidence of prostate cancer has led to a focus on prevention and treatment strategies to reduce the impact of this disease in public health. Boron compounds are increasingly recognized as preventative and chemotherapeutic agents. However, systemic administration of soluble boron compoun...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xia, Wang, Xiupeng, Zhang, Jun, Hanagata, Nobutaka, Wang, Xuebin, Weng, Qunhong, Ito, Atsuo, Bando, Yoshio, Golberg, Dmitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228389/
https://www.ncbi.nlm.nih.gov/pubmed/28059072
http://dx.doi.org/10.1038/ncomms13936
_version_ 1782493951423414272
author Li, Xia
Wang, Xiupeng
Zhang, Jun
Hanagata, Nobutaka
Wang, Xuebin
Weng, Qunhong
Ito, Atsuo
Bando, Yoshio
Golberg, Dmitri
author_facet Li, Xia
Wang, Xiupeng
Zhang, Jun
Hanagata, Nobutaka
Wang, Xuebin
Weng, Qunhong
Ito, Atsuo
Bando, Yoshio
Golberg, Dmitri
author_sort Li, Xia
collection PubMed
description High global incidence of prostate cancer has led to a focus on prevention and treatment strategies to reduce the impact of this disease in public health. Boron compounds are increasingly recognized as preventative and chemotherapeutic agents. However, systemic administration of soluble boron compounds is hampered by their short half-life and low effectiveness. Here we report on hollow boron nitride (BN) spheres with controlled crystallinity and boron release that decrease cell viability and increase prostate cancer cell apoptosis. In vivo experiments on subcutaneous tumour mouse models treated with BN spheres demonstrated significant suppression of tumour growth. An orthotopic tumour growth model was also utilized and further confirmed the in vivo anti-cancer efficacy of BN spheres. Moreover, the administration of hollow BN spheres with paclitaxel leads to synergetic effects in the suppression of tumour growth. The work demonstrates that hollow BN spheres may function as a new agent for prostate cancer treatment.
format Online
Article
Text
id pubmed-5228389
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-52283892017-02-01 Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment Li, Xia Wang, Xiupeng Zhang, Jun Hanagata, Nobutaka Wang, Xuebin Weng, Qunhong Ito, Atsuo Bando, Yoshio Golberg, Dmitri Nat Commun Article High global incidence of prostate cancer has led to a focus on prevention and treatment strategies to reduce the impact of this disease in public health. Boron compounds are increasingly recognized as preventative and chemotherapeutic agents. However, systemic administration of soluble boron compounds is hampered by their short half-life and low effectiveness. Here we report on hollow boron nitride (BN) spheres with controlled crystallinity and boron release that decrease cell viability and increase prostate cancer cell apoptosis. In vivo experiments on subcutaneous tumour mouse models treated with BN spheres demonstrated significant suppression of tumour growth. An orthotopic tumour growth model was also utilized and further confirmed the in vivo anti-cancer efficacy of BN spheres. Moreover, the administration of hollow BN spheres with paclitaxel leads to synergetic effects in the suppression of tumour growth. The work demonstrates that hollow BN spheres may function as a new agent for prostate cancer treatment. Nature Publishing Group 2017-01-06 /pmc/articles/PMC5228389/ /pubmed/28059072 http://dx.doi.org/10.1038/ncomms13936 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Li, Xia
Wang, Xiupeng
Zhang, Jun
Hanagata, Nobutaka
Wang, Xuebin
Weng, Qunhong
Ito, Atsuo
Bando, Yoshio
Golberg, Dmitri
Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment
title Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment
title_full Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment
title_fullStr Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment
title_full_unstemmed Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment
title_short Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment
title_sort hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228389/
https://www.ncbi.nlm.nih.gov/pubmed/28059072
http://dx.doi.org/10.1038/ncomms13936
work_keys_str_mv AT lixia hollowboronnitridenanospheresasboronreservoirforprostatecancertreatment
AT wangxiupeng hollowboronnitridenanospheresasboronreservoirforprostatecancertreatment
AT zhangjun hollowboronnitridenanospheresasboronreservoirforprostatecancertreatment
AT hanagatanobutaka hollowboronnitridenanospheresasboronreservoirforprostatecancertreatment
AT wangxuebin hollowboronnitridenanospheresasboronreservoirforprostatecancertreatment
AT wengqunhong hollowboronnitridenanospheresasboronreservoirforprostatecancertreatment
AT itoatsuo hollowboronnitridenanospheresasboronreservoirforprostatecancertreatment
AT bandoyoshio hollowboronnitridenanospheresasboronreservoirforprostatecancertreatment
AT golbergdmitri hollowboronnitridenanospheresasboronreservoirforprostatecancertreatment