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t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review
The chromosomal abnormality t(14;18)(q32;q21) is most commonly associated with germinal center-derived B-cell lymphomas, particularly follicular lymphoma (FL). Generally, it is considered a hallmark of FL. The t(14;18)(q32;q21) translocation is rare in chronic lymphocytic leukemia (CLL) and its prog...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228458/ https://www.ncbi.nlm.nih.gov/pubmed/28105149 http://dx.doi.org/10.3892/ol.2016.5258 |
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author | Chen, Weifeng Miao, Yi Wang, Rong Wu, Yujie Qiu, Hairong Xu, Wei Li, Jianyong Fan, Lei Xu, Xin |
author_facet | Chen, Weifeng Miao, Yi Wang, Rong Wu, Yujie Qiu, Hairong Xu, Wei Li, Jianyong Fan, Lei Xu, Xin |
author_sort | Chen, Weifeng |
collection | PubMed |
description | The chromosomal abnormality t(14;18)(q32;q21) is most commonly associated with germinal center-derived B-cell lymphomas, particularly follicular lymphoma (FL). Generally, it is considered a hallmark of FL. The t(14;18)(q32;q21) translocation is rare in chronic lymphocytic leukemia (CLL) and its prognostic significance remains unclear. In the present study, two cases of CLL with t(14;18)(q32;q21) were diagnosed using conventional cytogenetic analysis and fluorescence in situ hybridization. Both patients presented with leukemia and the morphological features and immunophenotypes were typical of CLL. Case 2 underwent a further lymph node biopsy, which established a diagnosis of CD5(–) CLL/small lymphocyte lymphoma. In addition to t(14;18)(q32;q21), trisomy 12 was identified in the same clone in Case 2. Both cases exhibited immunoglobulin heavy chain variable mutations, and heavy-chain variable region gene (VH) 4–39 and VH3-62 were used in Case 1 and Case 2, respectively. In addition, direct Sanger sequencing of exons 4–9 revealed that Case 2 harbored the tumor protein p53 mutation, c.829T>G. Both cases had indications for therapy. Case 1 responded well to chlorambucil treatment, and was still alive at the last follow-up. Conversely, Case 2 exhibited aggressive disease that appeared refractory to treatment, and eventually succumbed to the disease. |
format | Online Article Text |
id | pubmed-5228458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-52284582017-01-19 t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review Chen, Weifeng Miao, Yi Wang, Rong Wu, Yujie Qiu, Hairong Xu, Wei Li, Jianyong Fan, Lei Xu, Xin Oncol Lett Articles The chromosomal abnormality t(14;18)(q32;q21) is most commonly associated with germinal center-derived B-cell lymphomas, particularly follicular lymphoma (FL). Generally, it is considered a hallmark of FL. The t(14;18)(q32;q21) translocation is rare in chronic lymphocytic leukemia (CLL) and its prognostic significance remains unclear. In the present study, two cases of CLL with t(14;18)(q32;q21) were diagnosed using conventional cytogenetic analysis and fluorescence in situ hybridization. Both patients presented with leukemia and the morphological features and immunophenotypes were typical of CLL. Case 2 underwent a further lymph node biopsy, which established a diagnosis of CD5(–) CLL/small lymphocyte lymphoma. In addition to t(14;18)(q32;q21), trisomy 12 was identified in the same clone in Case 2. Both cases exhibited immunoglobulin heavy chain variable mutations, and heavy-chain variable region gene (VH) 4–39 and VH3-62 were used in Case 1 and Case 2, respectively. In addition, direct Sanger sequencing of exons 4–9 revealed that Case 2 harbored the tumor protein p53 mutation, c.829T>G. Both cases had indications for therapy. Case 1 responded well to chlorambucil treatment, and was still alive at the last follow-up. Conversely, Case 2 exhibited aggressive disease that appeared refractory to treatment, and eventually succumbed to the disease. D.A. Spandidos 2016-12 2016-10-13 /pmc/articles/PMC5228458/ /pubmed/28105149 http://dx.doi.org/10.3892/ol.2016.5258 Text en Copyright: © Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Chen, Weifeng Miao, Yi Wang, Rong Wu, Yujie Qiu, Hairong Xu, Wei Li, Jianyong Fan, Lei Xu, Xin t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review |
title | t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review |
title_full | t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review |
title_fullStr | t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review |
title_full_unstemmed | t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review |
title_short | t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review |
title_sort | t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: report of two cases and a literature review |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228458/ https://www.ncbi.nlm.nih.gov/pubmed/28105149 http://dx.doi.org/10.3892/ol.2016.5258 |
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