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Tumor suppressor candidate 3 as a novel predictor for lymph node metastasis in lung cancer patients

Tumor suppressor candidate 3 (TUSC3) was recently identified as a potential tumor suppressor gene in several cancer types. However, no data are currently available regarding the expression of TUSC3 in lung cancer. The present study investigated the expression of TUSC3 in patients with lung cancer an...

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Autores principales: Yu, Xinshuang, Zhang, Kaixian, Liu, Fengjun, Zhang, Jiandong, Zhai, Chunjuan, Cao, Lili, Song, Xingye, Wang, Yao, Li, Baosheng, Sun, Hongjun, Du, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228539/
https://www.ncbi.nlm.nih.gov/pubmed/28105217
http://dx.doi.org/10.3892/ol.2016.5333
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author Yu, Xinshuang
Zhang, Kaixian
Liu, Fengjun
Zhang, Jiandong
Zhai, Chunjuan
Cao, Lili
Song, Xingye
Wang, Yao
Li, Baosheng
Sun, Hongjun
Du, Juan
author_facet Yu, Xinshuang
Zhang, Kaixian
Liu, Fengjun
Zhang, Jiandong
Zhai, Chunjuan
Cao, Lili
Song, Xingye
Wang, Yao
Li, Baosheng
Sun, Hongjun
Du, Juan
author_sort Yu, Xinshuang
collection PubMed
description Tumor suppressor candidate 3 (TUSC3) was recently identified as a potential tumor suppressor gene in several cancer types. However, no data are currently available regarding the expression of TUSC3 in lung cancer. The present study investigated the expression of TUSC3 in patients with lung cancer and determined its association with the clinicopathological parameters of the disease. Cytoplasmic TUSC3 expression was evaluated by immunohistochemistry on tissue microarray slides, which included 35 small cell lung cancer (SCLC) specimens, 80 squamous cell lung cancer specimens (SCC), 80 adenocarcinoma lung cancer (ADC) specimens and 37 normal lung tissue specimens. Analysis showed significantly reduced TUSC3 expression in the SCLC patients, but not in the ADC and SCC patients, as compared with the normal controls. Additionally, TUSC3 expression in the patients with a degree of differentiation of 1–2 (well-moderately differentiated) was significantly higher than that in patients with a differentiation degree of 3–4 (poorly differentiated-undifferentiated). Further analysis showed that TUSC3 expression levels were negatively correlated with the degree of differentiation in the ADC and SCC patients. Notably, a marked decrease in TUSC3 expression was identified in the patients who were lymph node metastasis-positive (LNM(+)) compared with patients who were LNM(−). Further analysis showed that significant differences in TUSC3 expression were identified among the different N stages (LNM status) in the SCLC, ADC and SCC patients. Correlation analysis also identified a negative correlation between TUSC3 expression and LNM in all three pathological types of lung cancer tested. Overall, these results indicated that a reduction in TUSC3 may be associated with a poorly-differentiated grade of lung cancer. Importantly, TUSC3 expression may be a useful predictor of LNM in lung cancer patients. A combined analysis of TUSC3 expression and the clinical variables will aid in predicting the incidence of LNM.
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spelling pubmed-52285392017-01-19 Tumor suppressor candidate 3 as a novel predictor for lymph node metastasis in lung cancer patients Yu, Xinshuang Zhang, Kaixian Liu, Fengjun Zhang, Jiandong Zhai, Chunjuan Cao, Lili Song, Xingye Wang, Yao Li, Baosheng Sun, Hongjun Du, Juan Oncol Lett Articles Tumor suppressor candidate 3 (TUSC3) was recently identified as a potential tumor suppressor gene in several cancer types. However, no data are currently available regarding the expression of TUSC3 in lung cancer. The present study investigated the expression of TUSC3 in patients with lung cancer and determined its association with the clinicopathological parameters of the disease. Cytoplasmic TUSC3 expression was evaluated by immunohistochemistry on tissue microarray slides, which included 35 small cell lung cancer (SCLC) specimens, 80 squamous cell lung cancer specimens (SCC), 80 adenocarcinoma lung cancer (ADC) specimens and 37 normal lung tissue specimens. Analysis showed significantly reduced TUSC3 expression in the SCLC patients, but not in the ADC and SCC patients, as compared with the normal controls. Additionally, TUSC3 expression in the patients with a degree of differentiation of 1–2 (well-moderately differentiated) was significantly higher than that in patients with a differentiation degree of 3–4 (poorly differentiated-undifferentiated). Further analysis showed that TUSC3 expression levels were negatively correlated with the degree of differentiation in the ADC and SCC patients. Notably, a marked decrease in TUSC3 expression was identified in the patients who were lymph node metastasis-positive (LNM(+)) compared with patients who were LNM(−). Further analysis showed that significant differences in TUSC3 expression were identified among the different N stages (LNM status) in the SCLC, ADC and SCC patients. Correlation analysis also identified a negative correlation between TUSC3 expression and LNM in all three pathological types of lung cancer tested. Overall, these results indicated that a reduction in TUSC3 may be associated with a poorly-differentiated grade of lung cancer. Importantly, TUSC3 expression may be a useful predictor of LNM in lung cancer patients. A combined analysis of TUSC3 expression and the clinical variables will aid in predicting the incidence of LNM. D.A. Spandidos 2016-12 2016-11-02 /pmc/articles/PMC5228539/ /pubmed/28105217 http://dx.doi.org/10.3892/ol.2016.5333 Text en Copyright: © Yu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Yu, Xinshuang
Zhang, Kaixian
Liu, Fengjun
Zhang, Jiandong
Zhai, Chunjuan
Cao, Lili
Song, Xingye
Wang, Yao
Li, Baosheng
Sun, Hongjun
Du, Juan
Tumor suppressor candidate 3 as a novel predictor for lymph node metastasis in lung cancer patients
title Tumor suppressor candidate 3 as a novel predictor for lymph node metastasis in lung cancer patients
title_full Tumor suppressor candidate 3 as a novel predictor for lymph node metastasis in lung cancer patients
title_fullStr Tumor suppressor candidate 3 as a novel predictor for lymph node metastasis in lung cancer patients
title_full_unstemmed Tumor suppressor candidate 3 as a novel predictor for lymph node metastasis in lung cancer patients
title_short Tumor suppressor candidate 3 as a novel predictor for lymph node metastasis in lung cancer patients
title_sort tumor suppressor candidate 3 as a novel predictor for lymph node metastasis in lung cancer patients
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228539/
https://www.ncbi.nlm.nih.gov/pubmed/28105217
http://dx.doi.org/10.3892/ol.2016.5333
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