Cargando…

Prognostic impact of the tumor-infiltrating regulatory T-cell (Foxp3(+))/activated cytotoxic T lymphocyte (granzyme B(+)) ratio on resected left-sided pancreatic cancer

Among the subsets of tumor-infiltrating lymphocytes (TILs), activated cytotoxic T lymphocytes (granzyme B(+)) have an antitumor effect, while regulatory T lymphocytes [forkhead box P3 (Foxp3)(+)] suppress the antitumor immune response. The aim of the present study was to investigate the possible ass...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hwang, Ho Kyoung, Kim, Hyoung-Il, Kim, Se Hoon, Choi, Junjeong, Kang, Chang Moo, Kim, Kyung Sik, Lee, Woo Jung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228542/ https://www.ncbi.nlm.nih.gov/pubmed/28105157 http://dx.doi.org/10.3892/ol.2016.5252

Ejemplares similares

Yonsei Criteria, a Potential Linkage to Intratumoral Foxp3(+)/CD8(+) Ratio for the Prediction of Oncologic Outcomes in Resected Left-Sided Pancreatic Cancer
por: Hwang, Ho Kyoung, et al.
Publicado: (2020)

Granzyme B; the chalk-mark of a cytotoxic lymphocyte
por: Waterhouse, Nigel J, et al.
Publicado: (2004)

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes
Publicado: (1991)

Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes
por: Lu, Chunwan, et al.
Publicado: (2019)

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A
Publicado: (1989)

Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis
por: Mellor-Heineke, Sabine, et al.
Publicado: (2013)

Cytotoxic Lymphocytes Target HIV-1 Gag Through Granzyme M-Mediated Cleavage
por: Saccon, Elisa, et al.
Publicado: (2021)

Granzymes: The Molecular Executors of Immune-Mediated Cytotoxicity
por: Hay, Zachary L. Z., et al.
Publicado: (2022)

The ratio of CD8 + lymphocytes to tumor-infiltrating suppressive FOXP3 + effector regulatory T cells is associated with treatment response in invasive breast cancer
por: Goda, Noriko, et al.
Publicado: (2022)

Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse
por: Chitirala, Praneeth, et al.
Publicado: (2020)

The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastoma
por: Yue, Qi, et al.
Publicado: (2013)

Correlation between Lymphocyte-to-Monocyte Ratio (LMR), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR) and Tumor-Infiltrating Lymphocytes (TILs) in Left-Sided Colorectal Cancer Patients
por: Gawiński, Cieszymierz, et al.
Publicado: (2022)

Granzymes: a family of lymphocyte granule serine proteases
por: Trapani, Joseph A
Publicado: (2001)

Assessment of cytotoxic T-lymphocyte phenotype using the specific markers granzyme B and TIA-1 in cervical neoplastic lesions.
por: Bontkes, H. J., et al.
Publicado: (1997)

Fish Granzyme A Shows a Greater Role Than Granzyme B in Fish Innate Cell-Mediated Cytotoxicity
por: Chaves-Pozo, Elena, et al.
Publicado: (2019)

Tumour-infiltrating FOXP3(+) lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer
por: West, N R, et al.
Publicado: (2013)

G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes
por: Lu, Chunwan, et al.
Publicado: (2022)

The Association of CD8+ Cytotoxic T Cells and Granzyme B+ Lymphocytes with Immunosuppressive Factors, Tumor Stage and Prognosis in Cutaneous Melanoma
por: Salmi, Satu, et al.
Publicado: (2022)

Clinical significance of the preoperative platelet count and platelet-to-lymphocyte ratio (PLT-PLR) in patients with surgically resected non-small cell lung cancer
por: Kim, Seok-Hyun, et al.
Publicado: (2016)

Zonal Difference and Prognostic Significance of Foxp3 Regulatory T Cell Infiltration in Breast Cancer
por: Kim, Sewha, et al.
Publicado: (2014)

T cell receptor transgenic lymphocytes infiltrating murine tumors are not induced to express foxp3
por: Quatromoni, Jon G, et al.
Publicado: (2011)

FOXP1 negatively regulates tumor infiltrating lymphocyte migration in human breast cancer
por: De Silva, Pushpamali, et al.
Publicado: (2018)

Immunohistochemical Analysis of PD-1 and FOXP3 in Tumor-Infiltrating Lymphocytes in Human Gliomas
por: Kanagaraj, Priyanka, et al.
Publicado: (2023)

Identification of an N staging system that predicts oncologic outcome in resected left-sided pancreatic cancer
por: Kim, Sung Hyun, et al.
Publicado: (2016)

Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis
por: Waterhouse, Nigel J., et al.
Publicado: (2006)

The Prognostic Value of FoxP3+ Tumour-Infiltrating Lymphocytes in Rectal Cancer Depends on Immune Phenotypes Defined by CD8+ Cytotoxic T Cell Density
por: Schnellhardt, Sören, et al.
Publicado: (2022)

Prognostic value of intra‐tumoral CD8(+)/FoxP3(+) lymphocyte ratio in patients with resected colorectal cancer liver metastasis
por: Sideras, Kostandinos, et al.
Publicado: (2018)

Modulation of Inflammation by Extracellular Granzyme A
por: van Daalen, Kim R., et al.
Publicado: (2020)

The Role of Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in Predicting Neoadjuvant Chemotherapy Response in Breast Cancer
por: Kim, Hee Yeon, et al.
Publicado: (2019)

FOXP3 expression in tumor cells and tumor-infiltrating lymphocytes is associated with breast cancer prognosis
por: TAKENAKA, MIKI, et al.
Publicado: (2013)

Prognostic significance of FOXP3+ tumor-infiltrating lymphocytes in breast cancer depends on estrogen receptor and human epidermal growth factor receptor-2 expression status and concurrent cytotoxic T-cell infiltration
por: Liu, Shuzhen, et al.
Publicado: (2014)

C-reactive protein/albumin ratio and Glasgow prognostic score are associated with prognosis and infiltration of Foxp3+ or CD3+ lymphocytes in colorectal liver metastasis
por: Kanno, Hiroki, et al.
Publicado: (2022)

Spatial Differences in the Presence of FOXP3(+) and GranzymeB(+) T Cells between the Intra- and Extravascular Compartments in Renal Allograft Vasculopathy
por: de Boer, Onno J., et al.
Publicado: (2011)

T Regulatory CD4(+)CD25(+)FoxP3(+) Lymphocytes in the Peripheral Blood of Left-Sided Colorectal Cancer Patients
por: Dylag-Trojanowska, Katarzyna, et al.
Publicado: (2019)

Association between Novel Marker (Platelet-Lymphocyte Ratio, Neutrophil-Lymphocyte Ratio, and Delta Neutrophil Index) and Outcomes in Sudden Cardiac Arrest Patients
por: Han, Sang Il, et al.
Publicado: (2021)

Intracellular and Extracellular Roles of Granzyme K
por: Bouwman, Annemieke C., et al.
Publicado: (2021)

Granzymes are necessary for suppressive function of regulatory T cells
por: Co, Dominic O, et al.
Publicado: (2012)

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity
Publicado: (1995)

Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
por: Kaminski, Lea-Christina, et al.
Publicado: (2019)

A Genetically Encoded Dark-to-Bright Biosensor for Visualisation of Granzyme-Mediated Cytotoxicity
por: Bednar, Christopher, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_l9ncaf011cb6f4inun91agpkdp