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A decomposable silica-based antibacterial coating for percutaneous titanium implant
Although percutaneous titanium implants have become one of the best choices as retainers in the facial defects, peri-implantitis still occurs at a significant rate. This unwanted complication occurs due to adhesion of bacteria and subsequent biofilm formation. To solve this problem, we have develope...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5229168/ https://www.ncbi.nlm.nih.gov/pubmed/28123297 http://dx.doi.org/10.2147/IJN.S123622 |
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author | Wang, Jia Wu, Guofeng Liu, Xiangwei Sun, Guanyang Li, Dehua Wei, Hongbo |
author_facet | Wang, Jia Wu, Guofeng Liu, Xiangwei Sun, Guanyang Li, Dehua Wei, Hongbo |
author_sort | Wang, Jia |
collection | PubMed |
description | Although percutaneous titanium implants have become one of the best choices as retainers in the facial defects, peri-implantitis still occurs at a significant rate. This unwanted complication occurs due to adhesion of bacteria and subsequent biofilm formation. To solve this problem, we have developed a novel antibiotic nanodelivery system based on self-decomposable silica nanoparticles. In this study, silica-gentamycin (SG) nanoparticles were successfully fabricated using an innovative one-pot solution. The nanoparticles were incorporated within a gelatin matrix and cross-linked on microarc-oxidized titanium. To characterize the SG nanoparticles, their particle size, zeta potential, surface morphology, in vitro drug release, and decomposition process were sequentially evaluated. The antibacterial properties against the gram-positive Staphylococcus aureus, including bacterial viability, antibacterial rate, and bacteria morphology, were analyzed using SG-loaded titanium specimens. Any possible influence of released gentamycin on the viability of human fibroblasts, which are the main component of soft tissues, was investigated. SG nanoparticles from the antibacterial titanium coating continuously released gentamycin and inhibited S. aureus growth. In vitro investigation showed that the obtained nanodelivery system has good biocompatibility. Therefore, this design can be further investigated as a method to prevent infection around percutaneous implants. |
format | Online Article Text |
id | pubmed-5229168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-52291682017-01-25 A decomposable silica-based antibacterial coating for percutaneous titanium implant Wang, Jia Wu, Guofeng Liu, Xiangwei Sun, Guanyang Li, Dehua Wei, Hongbo Int J Nanomedicine Original Research Although percutaneous titanium implants have become one of the best choices as retainers in the facial defects, peri-implantitis still occurs at a significant rate. This unwanted complication occurs due to adhesion of bacteria and subsequent biofilm formation. To solve this problem, we have developed a novel antibiotic nanodelivery system based on self-decomposable silica nanoparticles. In this study, silica-gentamycin (SG) nanoparticles were successfully fabricated using an innovative one-pot solution. The nanoparticles were incorporated within a gelatin matrix and cross-linked on microarc-oxidized titanium. To characterize the SG nanoparticles, their particle size, zeta potential, surface morphology, in vitro drug release, and decomposition process were sequentially evaluated. The antibacterial properties against the gram-positive Staphylococcus aureus, including bacterial viability, antibacterial rate, and bacteria morphology, were analyzed using SG-loaded titanium specimens. Any possible influence of released gentamycin on the viability of human fibroblasts, which are the main component of soft tissues, was investigated. SG nanoparticles from the antibacterial titanium coating continuously released gentamycin and inhibited S. aureus growth. In vitro investigation showed that the obtained nanodelivery system has good biocompatibility. Therefore, this design can be further investigated as a method to prevent infection around percutaneous implants. Dove Medical Press 2017-01-06 /pmc/articles/PMC5229168/ /pubmed/28123297 http://dx.doi.org/10.2147/IJN.S123622 Text en © 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Wang, Jia Wu, Guofeng Liu, Xiangwei Sun, Guanyang Li, Dehua Wei, Hongbo A decomposable silica-based antibacterial coating for percutaneous titanium implant |
title | A decomposable silica-based antibacterial coating for percutaneous titanium implant |
title_full | A decomposable silica-based antibacterial coating for percutaneous titanium implant |
title_fullStr | A decomposable silica-based antibacterial coating for percutaneous titanium implant |
title_full_unstemmed | A decomposable silica-based antibacterial coating for percutaneous titanium implant |
title_short | A decomposable silica-based antibacterial coating for percutaneous titanium implant |
title_sort | decomposable silica-based antibacterial coating for percutaneous titanium implant |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5229168/ https://www.ncbi.nlm.nih.gov/pubmed/28123297 http://dx.doi.org/10.2147/IJN.S123622 |
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