Cargando…

A decomposable silica-based antibacterial coating for percutaneous titanium implant

Although percutaneous titanium implants have become one of the best choices as retainers in the facial defects, peri-implantitis still occurs at a significant rate. This unwanted complication occurs due to adhesion of bacteria and subsequent biofilm formation. To solve this problem, we have develope...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jia, Wu, Guofeng, Liu, Xiangwei, Sun, Guanyang, Li, Dehua, Wei, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5229168/
https://www.ncbi.nlm.nih.gov/pubmed/28123297
http://dx.doi.org/10.2147/IJN.S123622
_version_ 1782494070361292800
author Wang, Jia
Wu, Guofeng
Liu, Xiangwei
Sun, Guanyang
Li, Dehua
Wei, Hongbo
author_facet Wang, Jia
Wu, Guofeng
Liu, Xiangwei
Sun, Guanyang
Li, Dehua
Wei, Hongbo
author_sort Wang, Jia
collection PubMed
description Although percutaneous titanium implants have become one of the best choices as retainers in the facial defects, peri-implantitis still occurs at a significant rate. This unwanted complication occurs due to adhesion of bacteria and subsequent biofilm formation. To solve this problem, we have developed a novel antibiotic nanodelivery system based on self-decomposable silica nanoparticles. In this study, silica-gentamycin (SG) nanoparticles were successfully fabricated using an innovative one-pot solution. The nanoparticles were incorporated within a gelatin matrix and cross-linked on microarc-oxidized titanium. To characterize the SG nanoparticles, their particle size, zeta potential, surface morphology, in vitro drug release, and decomposition process were sequentially evaluated. The antibacterial properties against the gram-positive Staphylococcus aureus, including bacterial viability, antibacterial rate, and bacteria morphology, were analyzed using SG-loaded titanium specimens. Any possible influence of released gentamycin on the viability of human fibroblasts, which are the main component of soft tissues, was investigated. SG nanoparticles from the antibacterial titanium coating continuously released gentamycin and inhibited S. aureus growth. In vitro investigation showed that the obtained nanodelivery system has good biocompatibility. Therefore, this design can be further investigated as a method to prevent infection around percutaneous implants.
format Online
Article
Text
id pubmed-5229168
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-52291682017-01-25 A decomposable silica-based antibacterial coating for percutaneous titanium implant Wang, Jia Wu, Guofeng Liu, Xiangwei Sun, Guanyang Li, Dehua Wei, Hongbo Int J Nanomedicine Original Research Although percutaneous titanium implants have become one of the best choices as retainers in the facial defects, peri-implantitis still occurs at a significant rate. This unwanted complication occurs due to adhesion of bacteria and subsequent biofilm formation. To solve this problem, we have developed a novel antibiotic nanodelivery system based on self-decomposable silica nanoparticles. In this study, silica-gentamycin (SG) nanoparticles were successfully fabricated using an innovative one-pot solution. The nanoparticles were incorporated within a gelatin matrix and cross-linked on microarc-oxidized titanium. To characterize the SG nanoparticles, their particle size, zeta potential, surface morphology, in vitro drug release, and decomposition process were sequentially evaluated. The antibacterial properties against the gram-positive Staphylococcus aureus, including bacterial viability, antibacterial rate, and bacteria morphology, were analyzed using SG-loaded titanium specimens. Any possible influence of released gentamycin on the viability of human fibroblasts, which are the main component of soft tissues, was investigated. SG nanoparticles from the antibacterial titanium coating continuously released gentamycin and inhibited S. aureus growth. In vitro investigation showed that the obtained nanodelivery system has good biocompatibility. Therefore, this design can be further investigated as a method to prevent infection around percutaneous implants. Dove Medical Press 2017-01-06 /pmc/articles/PMC5229168/ /pubmed/28123297 http://dx.doi.org/10.2147/IJN.S123622 Text en © 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Wang, Jia
Wu, Guofeng
Liu, Xiangwei
Sun, Guanyang
Li, Dehua
Wei, Hongbo
A decomposable silica-based antibacterial coating for percutaneous titanium implant
title A decomposable silica-based antibacterial coating for percutaneous titanium implant
title_full A decomposable silica-based antibacterial coating for percutaneous titanium implant
title_fullStr A decomposable silica-based antibacterial coating for percutaneous titanium implant
title_full_unstemmed A decomposable silica-based antibacterial coating for percutaneous titanium implant
title_short A decomposable silica-based antibacterial coating for percutaneous titanium implant
title_sort decomposable silica-based antibacterial coating for percutaneous titanium implant
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5229168/
https://www.ncbi.nlm.nih.gov/pubmed/28123297
http://dx.doi.org/10.2147/IJN.S123622
work_keys_str_mv AT wangjia adecomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant
AT wuguofeng adecomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant
AT liuxiangwei adecomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant
AT sunguanyang adecomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant
AT lidehua adecomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant
AT weihongbo adecomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant
AT wangjia decomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant
AT wuguofeng decomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant
AT liuxiangwei decomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant
AT sunguanyang decomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant
AT lidehua decomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant
AT weihongbo decomposablesilicabasedantibacterialcoatingforpercutaneoustitaniumimplant